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Cleavage of plasma membrane calcium pumps by caspases : a link between apoptosis and necrosis

Cleavage of plasma membrane calcium pumps by caspases : a link between apoptosis and necrosis

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Prüfsumme: MD5:663df45fc1ec9ae83fd28fef4bb92a14

SCHWAB, Birgit Lisa, Danilo GUERINI, C. DIDSZUN, Daniele BANO, Elisa MAY, Eugenio FAVA, John TAM, D. XU, Steve XANTHOUDAKIS, Donald W. NICHOLSON, Ernesto CARAFOLI, Pierluigi NICOTERA, 2002. Cleavage of plasma membrane calcium pumps by caspases : a link between apoptosis and necrosis. In: Cell Death and Differentiation. 9(8), pp. 818-831. ISSN 1350-9047

@article{Schwab2002-08Cleav-18247, title={Cleavage of plasma membrane calcium pumps by caspases : a link between apoptosis and necrosis}, year={2002}, doi={10.1038/sj.cdd.4401042}, number={8}, volume={9}, issn={1350-9047}, journal={Cell Death and Differentiation}, pages={818--831}, author={Schwab, Birgit Lisa and Guerini, Danilo and Didszun, C. and Bano, Daniele and May, Elisa and Fava, Eugenio and Tam, John and Xu, D. and Xanthoudakis, Steve and Nicholson, Donald W. and Carafoli, Ernesto and Nicotera, Pierluigi} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/18247"> <dcterms:abstract xml:lang="eng">Neuronal death, which follows ischemic injury or is triggered by excitotoxins, can occur by both apoptosis and necrosis. Caspases, which are not directly required for necrotic cell death, are centralmediators of the apoptotic program.Herewe demonstrate that caspases cleave and inactivate the plasma membrane Ca2+ pump (PMCA) in neurons and non-neuronal cells undergoing apoptosis. PMCA cleavage impairs intracellular Ca2+ handling, which results in Ca2+ overload. Expression of non-cleavable PMCA mutants prevents the disturbance in Ca2+ handling, slows down the kinetics of apoptosis, and markedly delays secondary cell lysis (necrosis). These findings suggest that caspase-mediated cleavage and inactivation of PMCAs can lead to necrosis, an event that is reduced by caspase inhibitors in brain ischemia.</dcterms:abstract> <dcterms:bibliographicCitation>First publ. in: Cell Death and Differentiation ; 9 (2002), 8. - S. 818-831</dcterms:bibliographicCitation> <dc:creator>Nicotera, Pierluigi</dc:creator> <dc:creator>Carafoli, Ernesto</dc:creator> <dc:creator>Xu, D.</dc:creator> <dc:contributor>Bano, Daniele</dc:contributor> <dc:contributor>Fava, Eugenio</dc:contributor> <dcterms:issued>2002-08</dcterms:issued> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/18247"/> <dc:rights>deposit-license</dc:rights> <dcterms:title>Cleavage of plasma membrane calcium pumps by caspases : a link between apoptosis and necrosis</dcterms:title> <dc:creator>Xanthoudakis, Steve</dc:creator> <dc:contributor>Schwab, Birgit Lisa</dc:contributor> <dc:creator>Nicholson, Donald W.</dc:creator> <dc:contributor>Nicholson, Donald W.</dc:contributor> <dc:creator>Schwab, Birgit Lisa</dc:creator> <dc:contributor>May, Elisa</dc:contributor> <dc:contributor>Didszun, C.</dc:contributor> <dc:creator>Bano, Daniele</dc:creator> <dc:contributor>Carafoli, Ernesto</dc:contributor> <dc:contributor>Guerini, Danilo</dc:contributor> <dc:creator>Didszun, C.</dc:creator> <dc:creator>Fava, Eugenio</dc:creator> <dc:contributor>Nicotera, Pierluigi</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:contributor>Xu, D.</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-03-19T13:10:36Z</dc:date> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-03-19T13:10:36Z</dcterms:available> <dc:contributor>Xanthoudakis, Steve</dc:contributor> <dc:creator>Tam, John</dc:creator> <dc:contributor>Tam, John</dc:contributor> <dc:creator>Guerini, Danilo</dc:creator> <dc:creator>May, Elisa</dc:creator> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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