RPTPalpha is essential for NCAM-mediated p59fyn activation and neurite elongation

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BODRIKOV, Vsevolod, Iryna LESHCHYNS'KA, Vladimir SYTNYK, John OVERVOORDE, Melitta SCHACHNER, Jeroen de HERTOG, 2005. RPTPalpha is essential for NCAM-mediated p59fyn activation and neurite elongation. In: The journal of biological chemistry : JBC. 168(1), pp. 127-139. ISSN 0021-9525. eISSN 1540-8140

@article{Bodrikov2005RPTPa-18218, title={RPTPalpha is essential for NCAM-mediated p59fyn activation and neurite elongation}, year={2005}, doi={10.1083/jcb.200405073}, number={1}, volume={168}, issn={0021-9525}, journal={The journal of biological chemistry : JBC}, pages={127--139}, author={Bodrikov, Vsevolod and Leshchyns'ka, Iryna and Sytnyk, Vladimir and Overvoorde, John and Schachner, Melitta and Hertog, Jeroen de} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/18218"> <dc:creator>Overvoorde, John</dc:creator> <dcterms:title>RPTPalpha is essential for NCAM-mediated p59fyn activation and neurite elongation</dcterms:title> <dc:rights>deposit-license</dc:rights> <dc:creator>Bodrikov, Vsevolod</dc:creator> <dc:creator>Schachner, Melitta</dc:creator> <dc:contributor>Bodrikov, Vsevolod</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-03-20T10:00:00Z</dcterms:available> <dcterms:abstract xml:lang="eng">The neural cell adhesion molecule (NCAM) forms a complex with p59fyn kinase and activates it via a mechanism that has remained unknown. We show that the NCAM140 isoform directly interacts with the intracellular domain of the receptor-like protein tyrosine phosphatase RPTPalpha, a known activator of p59fyn. Whereas this direct interaction is Ca2+ independent, formation of the complex is enhanced by Ca2+-dependent spectrin cytoskeleton-mediated cross-linking of NCAM and RPTPalpha in response to NCAM activation and is accompanied by redistribution of the complex to lipid rafts. Association between NCAM and p59fyn is lost in RPTPalpha-deficient brains and is disrupted by dominant-negative RPTPalpha mutants, demonstrating that RPTPalpha is a link between NCAM and p59fyn. NCAM-mediated p59fyn activation is abolished in RPTPalpha-deficient neurons, and disruption of the NCAM-p59fyn complex in RPTPalpha-deficient neurons or with dominant-negative RPTPalpha mutants blocks NCAM-dependent neurite outgrowth, implicating RPTPalpha as a major phosphatase involved in NCAM-mediated signaling.</dcterms:abstract> <dc:contributor>Leshchyns'ka, Iryna</dc:contributor> <dc:language>eng</dc:language> <dcterms:bibliographicCitation>First publ. in: The journal of biological chemistry : JBC ; 168 (2005), 1. - S. 127-139</dcterms:bibliographicCitation> <dc:contributor>Schachner, Melitta</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/18218"/> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:contributor>Sytnyk, Vladimir</dc:contributor> <dc:creator>Leshchyns'ka, Iryna</dc:creator> <dcterms:issued>2005</dcterms:issued> <dc:creator>Hertog, Jeroen de</dc:creator> <dc:contributor>Hertog, Jeroen de</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-03-20T10:00:00Z</dc:date> <dc:contributor>Overvoorde, John</dc:contributor> <dc:creator>Sytnyk, Vladimir</dc:creator> </rdf:Description> </rdf:RDF>

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