The antiviral immune response in mice devoid of immunoproteasome activity

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BASLER, Michael, Ulrike BECK, Christopher J. KIRK, Marcus GRÖTTRUP, 2011. The antiviral immune response in mice devoid of immunoproteasome activity. In: The Journal of Immunology. 187(11), pp. 5548-5557. ISSN 0022-1767. eISSN 1550-6606. Available under: doi: 10.4049/jimmunol.1101064

@article{Basler2011-12-01antiv-18134, title={The antiviral immune response in mice devoid of immunoproteasome activity}, year={2011}, doi={10.4049/jimmunol.1101064}, number={11}, volume={187}, issn={0022-1767}, journal={The Journal of Immunology}, pages={5548--5557}, author={Basler, Michael and Beck, Ulrike and Kirk, Christopher J. and Gröttrup, Marcus} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/18134"> <dc:creator>Kirk, Christopher J.</dc:creator> <dcterms:bibliographicCitation>Publ. in: The Journal of Immunology ; 187 (2011), 11. - S. 5548-5557</dcterms:bibliographicCitation> <dcterms:issued>2011-12-01</dcterms:issued> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-02-02T07:55:49Z</dcterms:available> <dc:contributor>Kirk, Christopher J.</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/18134"/> <dc:creator>Beck, Ulrike</dc:creator> <dc:creator>Basler, Michael</dc:creator> <dc:language>eng</dc:language> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:abstract xml:lang="eng">The replacement of the catalytically active proteasome subunits β1, β2, and β5 by the immunoproteasome subunits low molecular mass polypeptide (LMP) 2 (β1i), multicatalytic endopeptidase complex-like-1 (MECL-1) (β2i), and LMP7 (β5i) is required for the production of numerous class I ligands. Hitherto, investigation of the immunoproteasome was confined to the analysis of mice deficient for one or two immunosubunits. In this study, we characterized LMP2(-/-)/MECL-1(-/-) double-deficient mice and used the well-defined LMP7-selective inhibitor ONX 0914 in these mice to generate mice lacking the activity of all immunoproteasome subunits. LMP2(-/-)/MECL-1(-/-) double-deficient mice had strongly reduced numbers of CD8(+) T cells in the spleen. Nevertheless, infection with the lymphocytic choriomeningits virus induced a normal cytotoxic T cell response in these mice, although the T cell response to several class I epitopes was altered. Treatment of LMP2(-/-)/MECL-1(-/-) double-deficient mice with the LMP7-selective inhibitor ONX 0914 elicited a strong CTL response in lymphocytic choriomeningitis virus-infected mice. Thereby, the T(CD8+) response to nucleoprotein 205-212, which is barely detectable in LMP2(-/-)/MECL-1(-/-) double-deficient mice, could be reverted to normal levels by LMP7 inhibition. Additional experiments could demonstrate that the increased CTL response to the nucleoprotein 205-212 in mice lacking functional immunoproteasome is due to an altered class I presentation of this epitope. Taken together, to our knowledge, this is the first study investigating viral infection in mice lacking activity of all three immunoproteasome subunits.</dcterms:abstract> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Gröttrup, Marcus</dc:creator> <dc:contributor>Basler, Michael</dc:contributor> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dc:contributor>Beck, Ulrike</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-02-02T07:55:49Z</dc:date> <dcterms:title>The antiviral immune response in mice devoid of immunoproteasome activity</dcterms:title> <dc:rights>deposit-license</dc:rights> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> </rdf:Description> </rdf:RDF>

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