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Cytotoxic dinuclear titanium-salan complexes : structural and biological characterization

Cytotoxic dinuclear titanium-salan complexes : structural and biological characterization

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IMMEL, Timo, Martin GRÜTZKE, Ellen BATROFF, Ulrich GROTH, Thomas HUHN, 2012. Cytotoxic dinuclear titanium-salan complexes : structural and biological characterization. In: Journal of Inorganic Biochemistry. 106(1), pp. 68-75. ISSN 0162-0134. eISSN 1873-3344

@article{Immel2012-01Cytot-17935, title={Cytotoxic dinuclear titanium-salan complexes : structural and biological characterization}, year={2012}, doi={10.1016/j.jinorgbio.2011.08.029}, number={1}, volume={106}, issn={0162-0134}, journal={Journal of Inorganic Biochemistry}, pages={68--75}, author={Immel, Timo and Grützke, Martin and Batroff, Ellen and Groth, Ulrich and Huhn, Thomas} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/17935"> <dc:creator>Huhn, Thomas</dc:creator> <dc:language>eng</dc:language> <dc:contributor>Grützke, Martin</dc:contributor> <dcterms:title>Cytotoxic dinuclear titanium-salan complexes : structural and biological characterization</dcterms:title> <dc:contributor>Immel, Timo</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/17935"/> <dc:contributor>Huhn, Thomas</dc:contributor> <dc:creator>Grützke, Martin</dc:creator> <dc:creator>Batroff, Ellen</dc:creator> <dc:contributor>Groth, Ulrich</dc:contributor> <dc:contributor>Batroff, Ellen</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-02-02T10:41:41Z</dcterms:available> <dc:creator>Immel, Timo</dc:creator> <dcterms:issued>2012-01</dcterms:issued> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-02-02T10:41:41Z</dc:date> <dcterms:bibliographicCitation>First publ. in: Journal of Inorganic Biochemistry ; 106 (2012), 1. - pp. 68-75</dcterms:bibliographicCitation> <dc:creator>Groth, Ulrich</dc:creator> <dcterms:abstract xml:lang="eng">Controlled hydrolysis of donor-substituted titanium-salan complexes led to the formation of well-defined dinuclear complexes. Structure determination by means of X-ray and NMR-studies revealed the presence of a single My-oxo bridge and one labile alkoxide ligand per titanium center. Concomitant cytotoxicity assays of the isolated dinuclear complexes showed cytotoxicities in the low micro-molar region, surpassing in this respect even their monomeric ancestors, thus making them possible highly active metabolites of titanium-salan anti-cancer drugs.</dcterms:abstract> <dc:rights>deposit-license</dc:rights> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> </rdf:Description> </rdf:RDF>

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Huhn etal.pdf 227

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