KOPS - Das Institutionelle Repositorium der Universität Konstanz

Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adults

Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adults

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

MÜNDERMANN, Annegret, Chris O. DYRBY, Thomas P. ANDRIACCHI, Karen B. KING, 2005. Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adults. In: Osteoarthritis and Cartilage. 13(1), pp. 34-38. ISSN 1063-4584. Available under: doi: 10.1016/j.joca.2004.09.007

@article{Mundermann2005-01Serum-17895, title={Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adults}, year={2005}, doi={10.1016/j.joca.2004.09.007}, number={1}, volume={13}, issn={1063-4584}, journal={Osteoarthritis and Cartilage}, pages={34--38}, author={Mündermann, Annegret and Dyrby, Chris O. and Andriacchi, Thomas P. and King, Karen B.} }

2005-01 Dyrby, Chris O. Mündermann, Annegret Andriacchi, Thomas P. 2012-02-06T07:31:29Z eng King, Karen B. Andriacchi, Thomas P. King, Karen B. Mündermann, Annegret 2012-02-06T07:31:29Z Publ. in: Osteoarthritis and Cartilage ; 13 (2005), 1. - S. 34-38 OBJECTIVE:<br />To test the hypothesis that physiological cyclic loading during a 30-min walking exercise causes an increase in serum cartilage oligomeric matrix protein (COMP) concentration in a healthy population.<br />METHODS:<br />Blood samples (5 ml) were drawn from 10 physically active adults immediately before and after, and 0.5h, 1.5h, 3.5h and 5.5h after a 30-min walking exercise on a level outdoor walking track at self-selected normal speed. On a separate day, blood samples were drawn from the same 10 subjects during 6h while they were resting in a chair. Serum COMP concentrations were determined using a commercial enzyme-linked immunosorbent assay (COMP ELISA). An activity monitor was used to record basic time-distance measurements of gait. Serum COMP concentrations within the exercise protocol and within the resting protocol were compared using separate repeated measures analyses of variance (alpha=0.05).<br />RESULTS:<br />In the exercise protocol, a first increase (9.7%; P=0.003) occurred immediately after the walking exercise. A second increase in serum COMP concentration (7.0%; P=0.024) occurred 5.5h after the walking exercise. In the resting protocol, the concentration at baseline was significantly higher than at all subsequent time points (8.2%; P<0.050). Serum COMP concentration decreased from the 3.5-h to the 5.5-h sample (-4.8%; P=0.012).<br />CONCLUSIONS:<br />Even a moderate walking activity can significantly influence serum COMP concentration. The immediate response points to a diffusion time of COMP fragments from cartilage to the blood of 30 min or less. The response at 5.5h indicates a metabolic delay for COMP in the range of 5h to 6h. Dyrby, Chris O. deposit-license Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adults

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto