KOPS - Das Institutionelle Repositorium der Universität Konstanz

Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4−10 and inhibit cytotoxicity and fibrillogenesis

Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4−10 and inhibit cytotoxicity and fibrillogenesis

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

MCLAURIN, JoAnne, Roxana CECAL, M. E. KIERSTEAD, Xiaodan TIAN, Amie L. PHINNEY, Marilena MANEA, J. E. FRENCH, Mark H. L. LAMBERMON, Audrey A. DARABIE, Mary E. BROWN, Christopher G JANUS, Muhammad Azhar CHISHTI, Patrick HORNE, David WESTAWAY, Paul FRASER, Howard MOUNT, Michael PRZYBYLSKI, Peter St. GEORGE-HYSLOP, 2002. Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4−10 and inhibit cytotoxicity and fibrillogenesis. In: Nature Medicine. 8(11), pp. 1263-1269. ISSN 1078-8956. Available under: doi: 10.1038/nm790

@article{McLaurin2002-11Thera-17582, title={Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4−10 and inhibit cytotoxicity and fibrillogenesis}, year={2002}, doi={10.1038/nm790}, number={11}, volume={8}, issn={1078-8956}, journal={Nature Medicine}, pages={1263--1269}, author={McLaurin, JoAnne and Cecal, Roxana and Kierstead, M. E. and Tian, Xiaodan and Phinney, Amie L. and Manea, Marilena and French, J. E. and Lambermon, Mark H. L. and Darabie, Audrey A. and Brown, Mary E. and Janus, Christopher G and Chishti, Muhammad Azhar and Horne, Patrick and Westaway, David and Fraser, Paul and Mount, Howard and Przybylski, Michael and George-Hyslop, Peter St.} }

McLaurin, JoAnne Cecal, Roxana Manea, Marilena Przybylski, Michael Immunization of transgenic mouse models of Alzheimer disease using amyloid-<sub>β</sub> peptide (A<sub>β</sub>) reduces both the Alzheimer disease−like neuropathology and the spatial memory impairments of these mice. However, a therapeutic trial of immunization with A<sub>β42</sub> in humans was discontinued because a few patients developed significant meningo-encephalitic cellular inflammatory reactions. Here we show that beneficial effects in mice arise from antibodies selectively directed against residues 4−10 of A<sub>β42</sub>, and that these antibodies inhibit both A<sub>β</sub> fibrillogenesis and cytotoxicity without eliciting an inflammatory response. These findings provide the basis for improved immunization antigens as well as attempts to design small-molecule mimics as alternative therapies. Cecal, Roxana Lambermon, Mark H. L. deposit-license Darabie, Audrey A. Fraser, Paul Mount, Howard Przybylski, Michael Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4−10 and inhibit cytotoxicity and fibrillogenesis Phinney, Amie L. Tian, Xiaodan Phinney, Amie L. Janus, Christopher G 2002-11 George-Hyslop, Peter St. Chishti, Muhammad Azhar 2012-01-18T08:57:21Z McLaurin, JoAnne Chishti, Muhammad Azhar Horne, Patrick French, J. E. eng Manea, Marilena Janus, Christopher G Publ. in: Nature Medicine ; 8 (2002), 11. - S. 1263-1269 Westaway, David Tian, Xiaodan Brown, Mary E. French, J. E. George-Hyslop, Peter St. Westaway, David Fraser, Paul Mount, Howard Horne, Patrick Darabie, Audrey A. Kierstead, M. E. 2012-01-18T08:57:21Z Lambermon, Mark H. L. Brown, Mary E. Kierstead, M. E.

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto