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Structure–function correlation of outer membrane protein porin from paracoccus denitrificans

Structure–function correlation of outer membrane protein porin from paracoccus denitrificans

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SUKUMARAN, Suja, Karin HAUSER, Elke MAIER, Roland BENZ, Werner MÄNTELE, 2006. Structure–function correlation of outer membrane protein porin from paracoccus denitrificans. In: Biopolymers. 82(4), pp. 344-348. ISSN 0006-3525

@article{Sukumaran2006-07Struc-17551, title={Structure–function correlation of outer membrane protein porin from paracoccus denitrificans}, year={2006}, doi={10.1002/bip.20422}, number={4}, volume={82}, issn={0006-3525}, journal={Biopolymers}, pages={344--348}, author={Sukumaran, Suja and Hauser, Karin and Maier, Elke and Benz, Roland and Mäntele, Werner} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/17551"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-02-28T09:22:21Z</dcterms:available> <dc:contributor>Hauser, Karin</dc:contributor> <dc:creator>Mäntele, Werner</dc:creator> <dcterms:bibliographicCitation>First publ. in: Biopolymers ; 82 (2006), 4. - pp. 344–348</dcterms:bibliographicCitation> <dc:contributor>Maier, Elke</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Benz, Roland</dc:creator> <dc:contributor>Sukumaran, Suja</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-02-28T09:22:21Z</dc:date> <dc:language>eng</dc:language> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/17551"/> <dc:contributor>Benz, Roland</dc:contributor> <dc:rights>deposit-license</dc:rights> <dc:contributor>Mäntele, Werner</dc:contributor> <dc:creator>Maier, Elke</dc:creator> <dc:creator>Hauser, Karin</dc:creator> <dcterms:title>Structure–function correlation of outer membrane protein porin from paracoccus denitrificans</dcterms:title> <dc:creator>Sukumaran, Suja</dc:creator> <dcterms:abstract xml:lang="eng">Porins from outer membrane of Gram-negative bacteria have a highly stable structure. Our previous studies on porin from Paracoccus denitrificans showed that the outer membrane protein porin is extremely stable toward heat, pH, and chemical denaturants. The major question we have addressed in this paper is whether the high stability of porin is a consequence of the b-barrel structure and whether it is required for its function. To explain this we have analyzed two cases: first, we used porin wild-type and mutants and compared their structure and function; second, we compared the activity of porin preheated to different temperatures. Structural changes were monitored by infrared spectroscopy. We observed that the structural stability of porin is not equivalent to functional activity as minor alteration in the structure can result in drastic differences in the activity of porins.</dcterms:abstract> <dcterms:issued>2006-07</dcterms:issued> </rdf:Description> </rdf:RDF>

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