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Identification of teleost Thy-1 and association with the microdomain/lipid raft reggie proteins in regenerating CNS axons

Identification of teleost Thy-1 and association with the microdomain/lipid raft reggie proteins in regenerating CNS axons

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DEININGER, Sören-Oliver, Lawrence RAJENDRAN, Friedrich LOTTSPEICH, Michael PRZYBYLSKI, Harald ILLGES, Claudia STÜRMER, Alexander REUTER, 2003. Identification of teleost Thy-1 and association with the microdomain/lipid raft reggie proteins in regenerating CNS axons. In: Molecular and Cellular Neuroscience. 22(4), pp. 544-554. ISSN 1044-7431

@article{Deininger2003Ident-17472, title={Identification of teleost Thy-1 and association with the microdomain/lipid raft reggie proteins in regenerating CNS axons}, year={2003}, doi={10.1016/S1044-7431(03)00028-9}, number={4}, volume={22}, issn={1044-7431}, journal={Molecular and Cellular Neuroscience}, pages={544--554}, author={Deininger, Sören-Oliver and Rajendran, Lawrence and Lottspeich, Friedrich and Przybylski, Michael and Illges, Harald and Stürmer, Claudia and Reuter, Alexander} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/17472"> <dc:contributor>Rajendran, Lawrence</dc:contributor> <dcterms:issued>2003</dcterms:issued> <dc:creator>Reuter, Alexander</dc:creator> <dcterms:bibliographicCitation>Publ. in: Molecular and Cellular Neuroscience ; 22 (2003), 4. - S. 544–554</dcterms:bibliographicCitation> <dc:creator>Illges, Harald</dc:creator> <dc:contributor>Illges, Harald</dc:contributor> <dcterms:title>Identification of teleost Thy-1 and association with the microdomain/lipid raft reggie proteins in regenerating CNS axons</dcterms:title> <dc:contributor>Lottspeich, Friedrich</dc:contributor> <dcterms:abstract xml:lang="deu">During regeneration, retinal ganglion cell axons in fish upregulate a cell surface protein that is recognized by the monoclonal antibody (mAB) M802. M802 antigen appeared to be linked to the intracellular, membrane-associated lipid raft/microdomain proteins reggie-1 and reggie-2 that were previously shown to be reexpressed in axon-regenerating neurons [Development 124 (1997), 577]. Here, we report the isolation of the M802 antigen and its identification as the teleost homolog of mammalian Thy-1. Fish Thy-1 is detected in the same detergent-insoluble lipid raft fractions from a fibroblast cell line and from axon regenerating retinae as reggie-1 and 2. Importantly, mAB M802 coimmunoprecipitates reggie-1 and 2 from this lipid raft fraction, implying that fish Thy-1 and reggies interact. This correlates with their colocalization in growing cell processes after M802 antigen/Thy-1 activation with mAB M802. These findings suggest a role of clustered M802 antigen/Thy-1 in reggie raft microdomains for cell growth and axon regeneration.</dcterms:abstract> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-01-18T15:32:13Z</dcterms:available> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/17472"/> <dc:creator>Przybylski, Michael</dc:creator> <dc:rights>deposit-license</dc:rights> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-01-18T15:32:13Z</dc:date> <dc:creator>Lottspeich, Friedrich</dc:creator> <dc:creator>Rajendran, Lawrence</dc:creator> <dc:language>deu</dc:language> <dc:contributor>Stürmer, Claudia</dc:contributor> <dc:creator>Deininger, Sören-Oliver</dc:creator> <dc:creator>Stürmer, Claudia</dc:creator> <dc:contributor>Przybylski, Michael</dc:contributor> <dc:contributor>Deininger, Sören-Oliver</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:contributor>Reuter, Alexander</dc:contributor> </rdf:Description> </rdf:RDF>

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