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Molecular Basis for Galactosylation of Core Fucose Residues in Invertebrates : Identification of Caenorhabditis elegans n-glycan core α1,6-FUCOSIDE β1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family

Molecular Basis for Galactosylation of Core Fucose Residues in Invertebrates : Identification of Caenorhabditis elegans n-glycan core α1,6-FUCOSIDE β1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family

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TITZ, Alexander, Alex BUTSCHI, Bernard HENRISSAT, Yao-Yun FAN, Thierry HENNET, Ebrahim RAZZAZI-FAZELI, Michael HENGARTNER, Iain WILSON, Markus KÜNZLER, Markus AEBI, 2009. Molecular Basis for Galactosylation of Core Fucose Residues in Invertebrates : Identification of Caenorhabditis elegans n-glycan core α1,6-FUCOSIDE β1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family. In: Journal of Biological Chemistry. 284(52), pp. 36223-36233. ISSN 0021-9258. eISSN 1083-351X

@article{Titz2009-12-25Molec-17122, title={Molecular Basis for Galactosylation of Core Fucose Residues in Invertebrates : Identification of Caenorhabditis elegans n-glycan core α1,6-FUCOSIDE β1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family}, year={2009}, doi={10.1074/jbc.M109.058354}, number={52}, volume={284}, issn={0021-9258}, journal={Journal of Biological Chemistry}, pages={36223--36233}, author={Titz, Alexander and Butschi, Alex and Henrissat, Bernard and Fan, Yao-Yun and Hennet, Thierry and Razzazi-Fazeli, Ebrahim and Hengartner, Michael and Wilson, Iain and Künzler, Markus and Aebi, Markus} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/17122"> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/17122"/> <dcterms:abstract xml:lang="eng">Galectin CGL2 from the ink cap mushroom Coprinopsis cinerea displays toxicity toward the model nematode Caenorhabditis elegans. A mutation in a putative glycosyltransferase-encoding gene resulted in a CGL2-resistant C. elegans strain characterized by N-glycans lacking the β1,4-galactoside linked to the α1,6-linked core fucose. Expression of the corresponding GALT-1 protein in insect cells was used to demonstrate a manganese-dependent galactosyltransferase activity. In vitro, the GALT-1 enzyme showed strong selectivity for acceptors with α1,6-linked N-glycan core fucosides and required Golgi- dependent modifications on the oligosaccharide antennae for optimal synthesis of the Gal-β1,4-fucose structure. Phylogenetic analysis of the GALT-1 protein sequence identified a novel glycosyltransferase family (GT92) with members widespread among eukarya but absent in mammals.</dcterms:abstract> <dc:contributor>Butschi, Alex</dc:contributor> <dc:contributor>Fan, Yao-Yun</dc:contributor> <dc:creator>Butschi, Alex</dc:creator> <dc:contributor>Razzazi-Fazeli, Ebrahim</dc:contributor> <dc:rights>deposit-license</dc:rights> <dcterms:issued>2009-12-25</dcterms:issued> <dc:creator>Wilson, Iain</dc:creator> <dc:contributor>Aebi, Markus</dc:contributor> <dc:contributor>Hengartner, Michael</dc:contributor> <dcterms:title>Molecular Basis for Galactosylation of Core Fucose Residues in Invertebrates : Identification of Caenorhabditis elegans n-glycan core α1,6-FUCOSIDE β1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family</dcterms:title> <dc:contributor>Titz, Alexander</dc:contributor> <dc:contributor>Henrissat, Bernard</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-11-29T10:22:30Z</dcterms:available> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Aebi, Markus</dc:creator> <dc:creator>Henrissat, Bernard</dc:creator> <dc:contributor>Hennet, Thierry</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-11-29T10:22:30Z</dc:date> <dc:language>eng</dc:language> <dcterms:bibliographicCitation>Publ. in: The Journal of Biological Chemistry ; 284 (2009), 52. - 36223</dcterms:bibliographicCitation> <dc:creator>Fan, Yao-Yun</dc:creator> <dc:creator>Künzler, Markus</dc:creator> <dc:contributor>Wilson, Iain</dc:contributor> <dc:creator>Hengartner, Michael</dc:creator> <dc:creator>Razzazi-Fazeli, Ebrahim</dc:creator> <dc:creator>Hennet, Thierry</dc:creator> <dc:creator>Titz, Alexander</dc:creator> <dc:contributor>Künzler, Markus</dc:contributor> </rdf:Description> </rdf:RDF>

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