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Direct corticospinal pathways contribute to neuromuscular control of perturbed stance

Direct corticospinal pathways contribute to neuromuscular control of perturbed stance

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TAUBE, Wolfgang, Martin SCHUBERT, Markus GRUBER, Sandra BECK, Michael FAIST, Albert GOLLHOFER, 2006. Direct corticospinal pathways contribute to neuromuscular control of perturbed stance. In: Journal of Applied Physiology. 101(2), pp. 420-429. ISSN 8750-7587

@article{Taube2006-08Direc-16981, title={Direct corticospinal pathways contribute to neuromuscular control of perturbed stance}, year={2006}, doi={10.1152/japplphysiol.01447.2005}, number={2}, volume={101}, issn={8750-7587}, journal={Journal of Applied Physiology}, pages={420--429}, author={Taube, Wolfgang and Schubert, Martin and Gruber, Markus and Beck, Sandra and Faist, Michael and Gollhofer, Albert} }

Gollhofer, Albert Beck, Sandra Faist, Michael Gruber, Markus Taube, Wolfgang The antigravity soleus muscle (Sol) is crucial for compensation of stance perturbation. A corticospinal contribution to the compensatory response of the Sol is under debate. The present study assessed spinal, corticospinal, and cortical excitability at the peaks of short- (SLR), medium- (MLR), and long-latency responses (LLR) after posterior translation of the feet. Transcranial magnetic stimulation (TMS) and peripheral nerve stimulation were individually adjusted so that the peaks of either motor evoked potential (MEP) or H reflex coincided with peaks of SLR, MLR, and LLR, respectively. The influence of specific, presumably direct, corticospinal pathways was investigated by H-reflex conditioning. When TMS was triggered so that the MEP arrived in the Sol at the same time as the peaks of SLR and MLR, EMG remained unaffected. Enhanced EMG was observed when the MEP coincided with the LLR peak (P < 0.001). Similarly, conditioning of the H reflex by subthreshold TMS facilitated H reflexes only at LLR (P < 0.001). The earliest facilitation after perturbation occurred after 86 ms. The TMS-induced H-reflex facilitation at LLR suggests that increased cortical excitability contributes to the augmentation of the LLR peaks. This provides evidence that the LLR in the Sol muscle is at least partly transcortical, involving direct corticospinal pathways. Additionally, these results demonstrate that approximately 86 ms after perturbation, postural compensatory responses are cortically mediated. 2006-08 Gollhofer, Albert Schubert, Martin Beck, Sandra deposit-license Taube, Wolfgang Publ. in: Journal of Applied Physiology ; 101 (2006), 2. - S. 420-429 2012-01-04T13:49:38Z Schubert, Martin Gruber, Markus Faist, Michael eng Direct corticospinal pathways contribute to neuromuscular control of perturbed stance 2012-01-04T13:49:38Z

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