Pulsation-resolved deep tissue dynamics measured with diffusing-wave spectroscopy

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LI, Jun, Gregor DIETSCHE, Georg MARET, Thomas GISLER, 2006. Pulsation-resolved deep tissue dynamics measured with diffusing-wave spectroscopy. In: Optics Express. 14(17), pp. 7841-7851. ISSN 1094-4087

@article{Li2006Pulsa-16952, title={Pulsation-resolved deep tissue dynamics measured with diffusing-wave spectroscopy}, year={2006}, doi={10.1364/OE.14.007841}, number={17}, volume={14}, issn={1094-4087}, journal={Optics Express}, pages={7841--7851}, author={Li, Jun and Dietsche, Gregor and Maret, Georg and Gisler, Thomas} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/16952"> <dcterms:title>Pulsation-resolved deep tissue dynamics measured with diffusing-wave spectroscopy</dcterms:title> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-01-18T20:12:19Z</dc:date> <dcterms:issued>2006</dcterms:issued> <dc:language>eng</dc:language> <dc:creator>Li, Jun</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-01-18T20:12:19Z</dcterms:available> <dcterms:bibliographicCitation>First publ. in: Optics Express ; 14 (2006), 17. - pp. 7841-7851</dcterms:bibliographicCitation> <dc:contributor>Dietsche, Gregor</dc:contributor> <dcterms:abstract xml:lang="eng">We present a technique for measuring transient microscopic dynamics within deep tissue with sub-second temporal resolution, using diffusing-wave spectroscopy with gated single-photon avalanche photodiodes (APDs) combined with standard ungated multi-tau correlators. Using the temporal autocorrelation function of a reference signal allows to correct the temporal intensity autocorrelation function of the sample signal for the distortions induced by the non-constant average photon count rate. We apply this technique to pulsation-synchronized measurements of tissue dynamics in humans. Measurements on the forearm show no dependence on the pulsation phase. In contrast, the decay rate of the DWS signal measured on the wrist over the radial artery shows a pulsation-induced modulation of 60−90% consistent with pulsatile variations of arterial erythrocyte flow velocity. This might make time-resolved DWS interesting as a sensitive and fast method for investigating deep tissue perfusion, e.g. in intensive care.</dcterms:abstract> <dc:rights>deposit-license</dc:rights> <dc:creator>Gisler, Thomas</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:contributor>Gisler, Thomas</dc:contributor> <dc:creator>Dietsche, Gregor</dc:creator> <dc:contributor>Maret, Georg</dc:contributor> <dc:contributor>Li, Jun</dc:contributor> <dc:creator>Maret, Georg</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/16952"/> </rdf:Description> </rdf:RDF>

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