Integrin-mediated uptake of fibronectin-binding bacteria


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HOFFMANN, Christine, Knut OHLSEN, Christof HAUCK, 2011. Integrin-mediated uptake of fibronectin-binding bacteria. In: European Journal of Cell Biology. 90(11), pp. 891-896. ISSN 0171-9335. eISSN 1618-1298. Available under: doi: 10.1016/j.ejcb.2011.03.001

@article{Hoffmann2011-11Integ-16829, title={Integrin-mediated uptake of fibronectin-binding bacteria}, year={2011}, doi={10.1016/j.ejcb.2011.03.001}, number={11}, volume={90}, issn={0171-9335}, journal={European Journal of Cell Biology}, pages={891--896}, author={Hoffmann, Christine and Ohlsen, Knut and Hauck, Christof} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:abstract>Invasion of mammalian cells via cell adhesion molecules of the integrin family is a common theme in bacterial pathogenesis. Whereas some microorganisms directly bind to integrins, other pathogens such as Staphylococcus aureus indirectly engage these receptors via fibronectin-binding proteins (FnBPs). In this review, we summarize the structure-function relationship of FnBPs and the current view of the role of these proteins during pathogenesis in vivo. A major focus will be on recent findings on the role of cholesterol- and sphingolipid-rich membrane microdomains for integrin-initiated uptake of fibronectin-binding bacteria and the surprising inhibitory function of caveolin-1 in this process. The detailed mechanistic understanding of host cell invasion by fibronectin-binding S. aureus can not only serve as a paradigm for other fibronectin-binding pathogenic bacteria, but might also reveal the physiological regulation of endocytosis of ligand-occupied integrins.</dcterms:abstract> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:isPartOfCollection rdf:resource=""/> <dc:contributor>Hoffmann, Christine</dc:contributor> <dc:creator>Ohlsen, Knut</dc:creator> <dcterms:rights rdf:resource=""/> <dc:creator>Hoffmann, Christine</dc:creator> <dc:date rdf:datatype="">2011-11-17T08:39:34Z</dc:date> <dc:contributor>Ohlsen, Knut</dc:contributor> <dcterms:bibliographicCitation>Publ. in: European Journal of Cell Biology ; 90 (2011), 11. - S. 891-896</dcterms:bibliographicCitation> <dcterms:available rdf:datatype="">2011-11-17T08:39:34Z</dcterms:available> <dc:creator>Hauck, Christof</dc:creator> <dcterms:issued>2011-11</dcterms:issued> <dc:contributor>Hauck, Christof</dc:contributor> <dc:language>eng</dc:language> <bibo:uri rdf:resource=""/> <dcterms:title>Integrin-mediated uptake of fibronectin-binding bacteria</dcterms:title> <dcterms:isPartOf rdf:resource=""/> <dc:rights>terms-of-use</dc:rights> </rdf:Description> </rdf:RDF>

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