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Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor

Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor

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RADTKE, Karl M., Martina RUF, Helen M. GUNTER, Katalin DOHRMANN, Maggie SCHAUER, Axel MEYER, Thomas ELBERT, 2011. Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. In: Translational Psychiatry. 1(7), e21. eISSN 2158-3188

@article{Radtke2011Trans-16715, title={Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor}, year={2011}, doi={10.1038/tp.2011.21}, number={7}, volume={1}, journal={Translational Psychiatry}, author={Radtke, Karl M. and Ruf, Martina and Gunter, Helen M. and Dohrmann, Katalin and Schauer, Maggie and Meyer, Axel and Elbert, Thomas}, note={Article Number: e21} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/16715"> <dc:contributor>Elbert, Thomas</dc:contributor> <dc:contributor>Meyer, Axel</dc:contributor> <dc:contributor>Schauer, Maggie</dc:contributor> <dc:creator>Gunter, Helen M.</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/16715"/> <dc:contributor>Dohrmann, Katalin</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-11-17T08:55:48Z</dc:date> <dc:contributor>Ruf, Martina</dc:contributor> <dc:creator>Schauer, Maggie</dc:creator> <dcterms:issued>2011</dcterms:issued> <dc:creator>Ruf, Martina</dc:creator> <dcterms:bibliographicCitation>Translational Psychiatry ; 1 (2011). - e21</dcterms:bibliographicCitation> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:title>Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor</dcterms:title> <dc:language>eng</dc:language> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-11-17T08:55:48Z</dcterms:available> <dc:contributor>Radtke, Karl M.</dc:contributor> <dc:creator>Dohrmann, Katalin</dc:creator> <dc:rights>deposit-license</dc:rights> <dcterms:abstract xml:lang="eng">Prenatal exposure to maternal stress can have lifelong implications for psychological function, such as behavioral problems and even the development of mental illness. Previous research suggests that this is due to transgenerational epigenetic programming of genes operating in the hypothalamic–pituitary–adrenal axis, such as the glucocorticoid receptor (GR). However, it is not known whether intrauterine exposure to maternal stress affects the epigenetic state of these genes beyond infancy. Here, we analyze the methylation status of the GR gene in mothers and their children, at 10–19 years after birth. We combine these data with a retrospective evaluation of maternal exposure to intimate partner violence (IPV). Methylation of the mother's GR gene was not affected by IPV. For the first time, we show that methylation status of the GR gene of adolescent children is influenced by their mother's experience of IPV during pregnancy. As these sustained epigenetic modifications are established in utero, we consider this to be a plausible mechanism by which prenatal stress may program adult psychosocial function.</dcterms:abstract> <dc:contributor>Gunter, Helen M.</dc:contributor> <dc:creator>Elbert, Thomas</dc:creator> <dc:creator>Radtke, Karl M.</dc:creator> <dc:creator>Meyer, Axel</dc:creator> </rdf:Description> </rdf:RDF>

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