Evolving a thermostable DNA polymerase that amplifies from highly damaged templates
| Type of Publication: | Journal article |
| URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-166988 |
| Author: | Glöckner, Christian; Sauter, Katharina B.; Marx, Andreas |
| Year of publication: | 2007 |
| Published in: | Angewandte Chemie International Edition ; 46 (2007), 17. - pp. 3115-3117. - ISSN 1433-7851 |
| Pubmed ID: | 17366498 |
| DOI (citable link): | https://dx.doi.org/10.1002/anie.200603987 |
| Summary: |
The foreign lesion: DNAs with damage generated, for example, by UV light are not good targets for standard replicative DNA polymerases. A DNA polymerase has been derived by directed evolution that faithfully amplifies light-damaged DNA. Interestingly, a single mutation is sufficient for this property
|
| Subject (DDC): | 540 Chemistry |
| Keywords: | directed evolution, DNA damage, DNA polymerase, polymerase chain reaction |
| Link to License: | Terms of use |
| Bibliography of Konstanz: | Yes |
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GLÖCKNER, Christian, Katharina B. SAUTER, Andreas MARX, 2007. Evolving a thermostable DNA polymerase that amplifies from highly damaged templates. In: Angewandte Chemie International Edition. 46(17), pp. 3115-3117. ISSN 1433-7851. Available under: doi: 10.1002/anie.200603987
@article{Glockner2007Evolv-16698, title={Evolving a thermostable DNA polymerase that amplifies from highly damaged templates}, year={2007}, doi={10.1002/anie.200603987}, number={17}, volume={46}, issn={1433-7851}, journal={Angewandte Chemie International Edition}, pages={3115--3117}, author={Glöckner, Christian and Sauter, Katharina B. and Marx, Andreas} }
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