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Evolving a thermostable DNA polymerase that amplifies from highly damaged templates

Evolving a thermostable DNA polymerase that amplifies from highly damaged templates

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GLÖCKNER, Christian, Katharina B. SAUTER, Andreas MARX, 2007. Evolving a thermostable DNA polymerase that amplifies from highly damaged templates. In: Angewandte Chemie International Edition. 46(17), pp. 3115-3117. ISSN 1433-7851

@article{Glockner2007Evolv-16698, title={Evolving a thermostable DNA polymerase that amplifies from highly damaged templates}, year={2007}, doi={10.1002/anie.200603987}, number={17}, volume={46}, issn={1433-7851}, journal={Angewandte Chemie International Edition}, pages={3115--3117}, author={Glöckner, Christian and Sauter, Katharina B. and Marx, Andreas} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/16698"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-11-16T09:10:07Z</dc:date> <dc:rights>deposit-license</dc:rights> <dc:contributor>Marx, Andreas</dc:contributor> <dc:contributor>Sauter, Katharina B.</dc:contributor> <dcterms:title>Evolving a thermostable DNA polymerase that amplifies from highly damaged templates</dcterms:title> <dc:creator>Glöckner, Christian</dc:creator> <dc:creator>Marx, Andreas</dc:creator> <dc:contributor>Glöckner, Christian</dc:contributor> <dcterms:issued>2007</dcterms:issued> <dcterms:bibliographicCitation>Publ. in: Angewandte Chemie / International Edition ; 46 (2007), 17. - S. 3115-3117</dcterms:bibliographicCitation> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-11-16T09:10:07Z</dcterms:available> <dc:language>eng</dc:language> <dc:creator>Sauter, Katharina B.</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/16698"/> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:abstract xml:lang="eng">The foreign lesion: DNAs with damage generated, for example, by UV light are not good targets for standard replicative DNA polymerases. A DNA polymerase has been derived by directed evolution that faithfully amplifies light-damaged DNA. Interestingly, a single mutation is sufficient for this property</dcterms:abstract> </rdf:Description> </rdf:RDF>

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