UBE1L2, a novel E1 enzyme specific for ubiquitin

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:e050bd8da7fd5450cedc05aa6264ac64

PELZER, Christiane, Ingrid KASSNER, Konstantin MATENTZOGLU, Rajesh K. SINGH, Hans-Peter WOLLSCHEID, Martin SCHEFFNER, Gunter SCHMIDTKE, Marcus GRÖTTRUP, 2007. UBE1L2, a novel E1 enzyme specific for ubiquitin. In: Journal of Biological Chemistry. 282(32), pp. 23010-23014. ISSN 0021-9258. Available under: doi: 10.1074/jbc.C700111200

@article{Pelzer2007-08-10UBE1L-16680, title={UBE1L2, a novel E1 enzyme specific for ubiquitin}, year={2007}, doi={10.1074/jbc.C700111200}, number={32}, volume={282}, issn={0021-9258}, journal={Journal of Biological Chemistry}, pages={23010--23014}, author={Pelzer, Christiane and Kassner, Ingrid and Matentzoglu, Konstantin and Singh, Rajesh K. and Wollscheid, Hans-Peter and Scheffner, Martin and Schmidtke, Gunter and Gröttrup, Marcus} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/16680"> <dc:contributor>Matentzoglu, Konstantin</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-11-16T06:52:03Z</dc:date> <dc:creator>Wollscheid, Hans-Peter</dc:creator> <dcterms:issued>2007-08-10</dcterms:issued> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/16680/2/Pelzer_166801.pdf"/> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dc:contributor>Singh, Rajesh K.</dc:contributor> <dc:rights>deposit-license</dc:rights> <dc:creator>Scheffner, Martin</dc:creator> <dc:creator>Gröttrup, Marcus</dc:creator> <dc:contributor>Schmidtke, Gunter</dc:contributor> <dc:contributor>Pelzer, Christiane</dc:contributor> <dcterms:abstract xml:lang="eng">UBE1 is known as the human ubiquitin-activating enzyme (E1), which activates ubiquitin in an ATP-dependent manner. Here, we identified a novel human ubiquitin-activating enzyme referred to as UBE1L2, which also shows specificity for ubiquitin. The UBE1L2 sequence displays a 40% identity to UBE1 and also contains an ATP-binding domain and an active site cysteine conserved among E1 family proteins. UBE1L2 forms a covalent link with ubiquitin in vitro and in vivo, which is sensitive to reducing conditions. In an in vitro polyubiquitylation assay, recombinant UBE1L2 could activate ubiquitin and transfer it onto the ubiquitin-conjugating enzyme UbcH5b. Ubiquitin activated by UBE1L2 could be used for ubiquitylation of p53 by MDM2 and supported the autoubiquitylation of the E3 ubiquitin ligases HectH9 and E6-AP. The UBE1L2 mRNA is most abundantly expressed in the testis, suggesting an organspecific regulation of ubiquitin activation.</dcterms:abstract> <dc:creator>Schmidtke, Gunter</dc:creator> <dc:contributor>Kassner, Ingrid</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Kassner, Ingrid</dc:creator> <dc:creator>Pelzer, Christiane</dc:creator> <dcterms:title>UBE1L2, a novel E1 enzyme specific for ubiquitin</dcterms:title> <dcterms:bibliographicCitation>Publ. in: Journal of Biological Chemistry ; 282 (2007), 32. - S. 23010-23014</dcterms:bibliographicCitation> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:language>eng</dc:language> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Scheffner, Martin</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/16680/2/Pelzer_166801.pdf"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-11-16T06:52:03Z</dcterms:available> <dc:creator>Singh, Rajesh K.</dc:creator> <dc:creator>Matentzoglu, Konstantin</dc:creator> <dc:contributor>Wollscheid, Hans-Peter</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/16680"/> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Pelzer_166801.pdf 31

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto