KOPS - Das Institutionelle Repositorium der Universität Konstanz

Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress

Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:a183949a7b239a89e13ff49a28c3dc86

SOMMERSHOF, Annette, Michael BASLER, Carsten RIETHER, Harald ENGLER, Marcus GRÖTTRUP, 2011. Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress. In: Brain, Behavior, and Immunity. 25(2), pp. 340-348. ISSN 0889-1591. eISSN 1090-2139

@article{Sommershof2011-02Atten-16318, title={Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress}, year={2011}, doi={10.1016/j.bbi.2010.10.016}, number={2}, volume={25}, issn={0889-1591}, journal={Brain, Behavior, and Immunity}, pages={340--348}, author={Sommershof, Annette and Basler, Michael and Riether, Carsten and Engler, Harald and Gröttrup, Marcus} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/16318"> <dc:contributor>Basler, Michael</dc:contributor> <dc:creator>Basler, Michael</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Gröttrup, Marcus</dc:creator> <dc:creator>Sommershof, Annette</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-01-05T10:56:34Z</dc:date> <dcterms:issued>2011-02</dcterms:issued> <dc:contributor>Engler, Harald</dc:contributor> <dc:rights>deposit-license</dc:rights> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-01-05T10:56:34Z</dcterms:available> <dc:contributor>Sommershof, Annette</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/16318"/> <dc:language>eng</dc:language> <dcterms:bibliographicCitation>First publ. in: Brain, Behavior, and Immunity ; 25 (2011), 2. - pp. 340-348</dcterms:bibliographicCitation> <dc:contributor>Riether, Carsten</dc:contributor> <dc:creator>Engler, Harald</dc:creator> <dcterms:title>Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress</dcterms:title> <dc:creator>Riether, Carsten</dc:creator> <dcterms:abstract xml:lang="eng">Chronic stress is suspected to increase the susceptibility to infections but experimental evidence from physiological stress models is scarce. We examined the effects of chronic social stress on virus-specific CTL responses in mice after infection with lymphocytic choriomeningitis virus (LCMV). Mice subjected to social stress on six consecutive days prior to infection showed a significant reduction of IFN-γ producing TCD8+ splenocytes and markedly lowered plasma concentrations of IFN-γ. In contrast, the generation of LCMV-specific CTL responses was not altered in mice undergoing the same stress procedure concurrently with infection. Furthermore, stress exposure 6 days before and additional 3 days after LCMV infection profoundly reduced the expansion of TCD8+ cells in the spleen, due to diminished in vivo proliferation. Pharmacological blockade of glucocorticoid receptors completely abrogated the stress-associated decline of TCD8+ expansion. Stressed mice showed a significantly reduced expression of the early T-cell activation marker CD69 as well as impaired in vitro cytokine secretion of IFN-γ and IL-2. Additionally, social stress led to an altered migration capacity of TCD8+ cells as demonstrated by adoptive T cell transfer experiments. Taken together, this study shows that chronic social stress fundamentally suppresses the functional capacities of T cells during a viral infection.</dcterms:abstract> <dc:contributor>Gröttrup, Marcus</dc:contributor> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Sommershof_Attenuation.pdf 106

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto