A new anticoagulant-antidote pair : Control of thrombin activity by aptamers and porphyrins
| Type of Publication: | Journal article |
| Author: | Joachimi, Astrid; Mayer, Günter; Hartig, Jörg |
| Year of publication: | 2007 |
| Published in: | Journal of the American Chemical Society ; 129 (2007), 11. - pp. 3036-3037. - ISSN 0002-7863 |
| Pubmed ID: | 17319665 |
| DOI (citable link): | https://dx.doi.org/10.1021/ja0677822 |
| Summary: |
Cationic porphyrins have been described to bind to G-quadruplexes with high affinities. In combination with G-quadruplex containing DNA aptamers that bind and inhibit the blood clotting factor thrombin, these molecules act as true antidotes that revert the anticoagulant activity of the aptamer. Porphyrins in concert with four-stranded aptamers therefore represent a novel anticoagulant/antidote class within the blood clotting cascade.
|
| Subject (DDC): | 540 Chemistry |
| Bibliography of Konstanz: | Yes |
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JOACHIMI, Astrid, Günter MAYER, Jörg HARTIG, 2007. A new anticoagulant-antidote pair : Control of thrombin activity by aptamers and porphyrins. In: Journal of the American Chemical Society. 129(11), pp. 3036-3037. ISSN 0002-7863. Available under: doi: 10.1021/ja0677822
@article{Joachimi2007-03-21antic-15622, title={A new anticoagulant-antidote pair : Control of thrombin activity by aptamers and porphyrins}, year={2007}, doi={10.1021/ja0677822}, number={11}, volume={129}, issn={0002-7863}, journal={Journal of the American Chemical Society}, pages={3036--3037}, author={Joachimi, Astrid and Mayer, Günter and Hartig, Jörg} }
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