A new anticoagulant-antidote pair : Control of thrombin activity by aptamers and porphyrins
| Publikationstyp: | Zeitschriftenartikel |
| Autor/innen: | Joachimi, Astrid; Mayer, Günter; Hartig, Jörg |
| Erscheinungsjahr: | 2007 |
| Erschienen in: | Journal of the American Chemical Society ; 129 (2007), 11. - S. 3036-3037. - ISSN 0002-7863 |
| Pubmed ID: | 17319665 |
| DOI (zitierfähiger Link): | https://dx.doi.org/10.1021/ja0677822 |
| Zusammenfassung: |
Cationic porphyrins have been described to bind to G-quadruplexes with high affinities. In combination with G-quadruplex containing DNA aptamers that bind and inhibit the blood clotting factor thrombin, these molecules act as true antidotes that revert the anticoagulant activity of the aptamer. Porphyrins in concert with four-stranded aptamers therefore represent a novel anticoagulant/antidote class within the blood clotting cascade.
|
| Fachgebiet (DDC): | 540 Chemie |
| Universitätsbibliographie: | Ja |
Zitieren
Dateien zu dieser Ressource
| Dateien | Größe | Format | Anzeige |
|---|---|---|---|
|
Zu diesem Dokument gibt es keine Dateien. |
|||
JOACHIMI, Astrid, Günter MAYER, Jörg HARTIG, 2007. A new anticoagulant-antidote pair : Control of thrombin activity by aptamers and porphyrins. In: Journal of the American Chemical Society. 129(11), pp. 3036-3037. ISSN 0002-7863. Available under: doi: 10.1021/ja0677822
@article{Joachimi2007-03-21antic-15622, title={A new anticoagulant-antidote pair : Control of thrombin activity by aptamers and porphyrins}, year={2007}, doi={10.1021/ja0677822}, number={11}, volume={129}, issn={0002-7863}, journal={Journal of the American Chemical Society}, pages={3036--3037}, author={Joachimi, Astrid and Mayer, Günter and Hartig, Jörg} }
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/15622"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-07T12:15:58Z</dcterms:available> <dcterms:rights rdf:resource="https://kops.uni-konstanz.de/page/termsofuse"/> <dc:creator>Hartig, Jörg</dc:creator> <dcterms:issued>2007-03-21</dcterms:issued> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Mayer, Günter</dc:contributor> <dc:creator>Joachimi, Astrid</dc:creator> <dcterms:title>A new anticoagulant-antidote pair : Control of thrombin activity by aptamers and porphyrins</dcterms:title> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Hartig, Jörg</dc:contributor> <dcterms:abstract xml:lang="eng">Cationic porphyrins have been described to bind to G-quadruplexes with high affinities. In combination with G-quadruplex containing DNA aptamers that bind and inhibit the blood clotting factor thrombin, these molecules act as true antidotes that revert the anticoagulant activity of the aptamer. Porphyrins in concert with four-stranded aptamers therefore represent a novel anticoagulant/antidote class within the blood clotting cascade.</dcterms:abstract> <dc:creator>Mayer, Günter</dc:creator> <dc:language>eng</dc:language> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/15622"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-07T12:15:58Z</dc:date> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dcterms:bibliographicCitation>Publ. in: Journal of the American Chemical Society ; 129 (2007), 11. pp. 3036-3027</dcterms:bibliographicCitation> <dc:contributor>Joachimi, Astrid</dc:contributor> </rdf:Description> </rdf:RDF>
Das Dokument erscheint in:
KOPS Suche
Stöbern
Mein Benutzerkonto
