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Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice

Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice

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MOEBIUS, Jacqueline, Maries van den BROEK, Marcus GRÖTTRUP, Michael BASLER, 2010. Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice. In: European Journal of Immunology. 40(12), pp. 3439-3449. ISSN 0014-2980. eISSN 1521-4141

@article{Moebius2010-12Immun-15154, title={Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice}, year={2010}, doi={10.1002/eji.201040620}, number={12}, volume={40}, issn={0014-2980}, journal={European Journal of Immunology}, pages={3439--3449}, author={Moebius, Jacqueline and Broek, Maries van den and Gröttrup, Marcus and Basler, Michael} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/15154"> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:title>Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice</dcterms:title> <dc:creator>Broek, Maries van den</dc:creator> <dc:language>eng</dc:language> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-31T06:46:06Z</dc:date> <dcterms:abstract xml:lang="eng">Immunoproteasomes containing the IFN-inducible subunits β1i (LMP2), β2i (MECL-1) and β5i (LMP7) alter proteasomal cleavage preference and optimize the generation of peptide ligands of MHC class I molecules. Here, we report on an unexpected new function of immunoproteasome subunits for the survival and expansion of CD4+ and CD8+ T cells during viral infection of mice. The effect of immunoproteasome subunit deficiency on T-cell survival upon adoptive transfer was most prominent for the lack of LMP7 followed by MECL-1 and LMP2. The survival of T cells in uninfected mice or the homeostatic expansion after transfer into RAG-2−/− mice was not affected by the lack of the immunosubunits. Lymphocytic choriomeningitis virus (LCMV)-specific CD8+ T cells lacking LMP7 or MECL-1 started to divide after transfer into LCMV-infected mice but experienced a considerable cell loss within 2 days after transfer. We provide strong evidence that the loss of immunoproteasome-deficient T cells after transfer is not a consequence of graft rejection by the host, but instead is based on the requirement for immunoproteasomes for the survival of T cells in LCMV-infected mice. Therefore, the immunoproteasome may qualify as a potential new target for the suppression of undesired proinflammatory T-cell responses.</dcterms:abstract> <dc:contributor>Broek, Maries van den</dc:contributor> <dc:contributor>Basler, Michael</dc:contributor> <dc:creator>Gröttrup, Marcus</dc:creator> <dcterms:issued>2010-12</dcterms:issued> <dcterms:bibliographicCitation>Publ. in: European Journal of Immunology ; 40 (2010), 12. - pp. 3439-3449</dcterms:bibliographicCitation> <dc:rights>deposit-license</dc:rights> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/15154"/> <dc:contributor>Moebius, Jacqueline</dc:contributor> <dc:creator>Moebius, Jacqueline</dc:creator> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dc:creator>Basler, Michael</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-31T06:46:06Z</dcterms:available> </rdf:Description> </rdf:RDF>

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