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Turning Inhibitors into Activators: A Guanine-Quadruplex-controlled Hammerhead Ribozyme

Turning Inhibitors into Activators: A Guanine-Quadruplex-controlled Hammerhead Ribozyme

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WIELAND, Markus, Jörg HARTIG, 2006. Turning Inhibitors into Activators: A Guanine-Quadruplex-controlled Hammerhead Ribozyme. Weinheim : Wiley-VCH. In: Angewandte Chemie International Edition. 45(35), pp. 5875-5878. ISSN 1433-7851

@article{Wieland2006-09-04Turni-15093, title={Turning Inhibitors into Activators: A Guanine-Quadruplex-controlled Hammerhead Ribozyme}, year={2006}, doi={10.1002/anie.200600909}, number={35}, volume={45}, issn={1433-7851}, journal={Angewandte Chemie International Edition}, pages={5875--5878}, author={Wieland, Markus and Hartig, Jörg} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/15093"> <dc:language>eng</dc:language> <dcterms:title>Turning Inhibitors into Activators: A Guanine-Quadruplex-controlled Hammerhead Ribozyme</dcterms:title> <dcterms:abstract xml:lang="eng">Modular design of functional RNAs can be used to tailor molecular properties. Guanosine-rich sequences were introduced as switching devices for functional nucleic acids. TMPyP4 (see picture) was identified as the strongest ribozyme inhibitor known to date. When quadruplex-forming, G-rich sequences were attached to the ribozyme, the TMPyP4-mediated response was inverted from inhibition to activation of the ribozyme reaction.</dcterms:abstract> <dcterms:issued>2006-09-04</dcterms:issued> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Wieland, Markus</dc:creator> <dc:rights>deposit-license</dc:rights> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-09-30T10:35:21Z</dc:date> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/15093"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-09-30T10:35:21Z</dcterms:available> <dcterms:bibliographicCitation>Publ. in: Angewandte Chemie / International Edition ; 45 (2006), 35. - pp. 5875 –5878</dcterms:bibliographicCitation> <dc:contributor>Wieland, Markus</dc:contributor> <dc:creator>Hartig, Jörg</dc:creator> <dc:publisher>Weinheim : Wiley-VCH</dc:publisher> <dc:contributor>Hartig, Jörg</dc:contributor> </rdf:Description> </rdf:RDF>

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