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Specific cognitive training normalizes auditory sensory gating in schizophrenia : a randomized trial

Specific cognitive training normalizes auditory sensory gating in schizophrenia : a randomized trial

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Prüfsumme: MD5:7c2db6a19a8c5ddadefa47d1a7bad28d

POPOV, Tzvetan, Todor JORDANOV, Brigitte ROCKSTROH, Thomas ELBERT, Michael MERZENICH, Gregory MILLER, 2011. Specific cognitive training normalizes auditory sensory gating in schizophrenia : a randomized trial. In: Biological Psychiatry. 69(5), pp. 465-471. ISSN 0006-3223. eISSN 1873-2402

@article{Popov2011-03-01Speci-14618, title={Specific cognitive training normalizes auditory sensory gating in schizophrenia : a randomized trial}, year={2011}, doi={10.1016/j.biopsych.2010.09.028}, number={5}, volume={69}, issn={0006-3223}, journal={Biological Psychiatry}, pages={465--471}, author={Popov, Tzvetan and Jordanov, Todor and Rockstroh, Brigitte and Elbert, Thomas and Merzenich, Michael and Miller, Gregory} }

eng First publ. in: Biological Psychiatry ; 69 (2011), 5. - pp. 465-471 Popov, Tzvetan Jordanov, Todor 2011-03-01 Specific cognitive training normalizes auditory sensory gating in schizophrenia : a randomized trial deposit-license Merzenich, Michael Background: The ratio of scalp-recorded brain responses occurring 50 msec after paired clicks (S2-evoked P50/S1-evoked P50) serves as a measure of sensory gating. An abnormally large ratio is commonly found in schizophrenia and is considered as a sign of reduced sensory<br />gating or otherwise dysfunctional organization of the auditory/verbal system as a factor contributing to psychopathology and cognitive<br />dysfunction in schizophrenia. This initial randomized clinical trial compared the efficacy of two 4-week, computer-based cognitive training<br />methods that emphasize either auditory discrimination and verbal memory or a broader range of cognitive functions in schizophrenia.<br />Methods: Thirty-nine schizophrenia patients (ICD-F20.0 diagnosis) were assigned to Cognitive Exercises (CE) or Cognitive Package (Cogpack).<br />The M50, the magnetoencephalographic analogue of electroencephalographic P50, and performance on verbal learning and<br />memory tests were used to evaluate training effects.<br />Results: As expected, patients exhibited higher pretreatment gating ratios than 28 age-matched healthy comparison participants. Gating<br />ratios decreased after CE but not after Cogpack. Cognitive test performance improved more after CE than after Cogpack.<br />Conclusions: Appropriately specific psychological training changes the neural performance in schizophrenia, normalizing sensory and cognitive function. 2011-10-27T09:55:45Z Elbert, Thomas Merzenich, Michael Elbert, Thomas Miller, Gregory Rockstroh, Brigitte 2011-10-27T09:55:45Z Miller, Gregory Popov, Tzvetan Rockstroh, Brigitte Jordanov, Todor

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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