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RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors

RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors

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BISCHOFF, Stephan C., Martin KRIEGER, Thomas BRUNNER, Antal ROT, Vincenz von TSCHARNER, Marco BAGGIOLINI, Clemens A. DAHINDEN, 1993. RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors. In: European Journal of Immunology. 23(3), pp. 761-767. ISSN 0014-2980

@article{Bischoff1993-03RANTE-14339, title={RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors}, year={1993}, doi={10.1002/eji.1830230329}, number={3}, volume={23}, issn={0014-2980}, journal={European Journal of Immunology}, pages={761--767}, author={Bischoff, Stephan C. and Krieger, Martin and Brunner, Thomas and Rot, Antal and Tscharner, Vincenz von and Baggiolini, Marco and Dahinden, Clemens A.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/14339"> <dc:creator>Bischoff, Stephan C.</dc:creator> <dc:contributor>Dahinden, Clemens A.</dc:contributor> <dc:contributor>Krieger, Martin</dc:contributor> <dcterms:issued>1993-03</dcterms:issued> <dc:language>eng</dc:language> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-24T08:28:13Z</dcterms:available> <dcterms:abstract xml:lang="eng">Chemotactic cytokines related to interleukin-8 (IL-8; CXC-chemokines) or monocyte chemotactic protein-1 (MCP-1; CC-chemokines) have been shown to stimulate human basophils, and are considered important tissue-derived mediators of inflammation. We have studied the effects of four CC-chemokines and show that MCP-1, RANTES (regulated on activation, normal T expressed and secreted) and macrophage inflammatory protein-lα (MlP-lα) are potent basophil agonists inducing a rapid change of cytosolic free calcium ([Ca2+]i), the release of histamine and sulfido-leukotrienes, and chemotaxis. MCP-1 was the most potent stimulus of release, and the only chemokine that induced marked exocytosis in basophils without pretreatment with interleukin-3. RANTES was the strongest stimulus of chemotaxis, but only a moderate stimulus of release. MIP-lα elicited relatively weak chemotaxis and release responses, but was effective at considerably lower concentrations than MCP-1 and RANTES. MIP-1β, by contrast, despite its high homology to MlP-lα, was totally inactive. Normodense human eosinophils, tested for comparison, responded in a similar fashion to RANTES and MIP-lα, but were unresponsive to MCP-1 and MIP-lβ. All CC-chemokines except MIP-lβ induced a similar rapid and transient rise of [Ca2+]| that was sensitive to pertussis toxin, indicating that they activate basophils via G-protein-coupled receptors. Cross-desensensitization experiments indicate that basophils bear different CC-chemokine receptors. Some interact selectively with MCP-1 or RANTES, while others are shared by RANTES and MlP-lα.</dcterms:abstract> <dc:rights>deposit-license</dc:rights> <dc:creator>Tscharner, Vincenz von</dc:creator> <dcterms:bibliographicCitation>Publ. in: European Journal of Immunology ; 23 (1993), 3. - S. 761-767</dcterms:bibliographicCitation> <dc:contributor>Bischoff, Stephan C.</dc:contributor> <dc:creator>Baggiolini, Marco</dc:creator> <dc:contributor>Baggiolini, Marco</dc:contributor> <dc:contributor>Brunner, Thomas</dc:contributor> <dcterms:title>RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors</dcterms:title> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14339"/> <dc:creator>Dahinden, Clemens A.</dc:creator> <dc:creator>Brunner, Thomas</dc:creator> <dc:contributor>Rot, Antal</dc:contributor> <dc:creator>Krieger, Martin</dc:creator> <dc:contributor>Tscharner, Vincenz von</dc:contributor> <dc:creator>Rot, Antal</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-24T08:28:13Z</dc:date> </rdf:Description> </rdf:RDF>

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