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Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T cell hybridomas

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T cell hybridomas

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BRUNNER, Thomas, Rona MOGIL, Drake LAFACE, Nam Jin YOO, Artin MAHBOUBI, Fernando ECHEVERRI, Seamus MARTIN, Walker FORCE, David LYNCH, Carl WARE, Douglas GREEN, 1995. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T cell hybridomas. In: Nature. 373(6513), pp. 441-444. ISSN 0028-0836

@article{Brunner1995-02-02Cell--14324, title={Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T cell hybridomas}, year={1995}, doi={10.1038/373441a0}, number={6513}, volume={373}, issn={0028-0836}, journal={Nature}, pages={441--444}, author={Brunner, Thomas and Mogil, Rona and LaFace, Drake and Yoo, Nam Jin and Mahboubi, Artin and Echeverri, Fernando and Martin, Seamus and Force, Walker and Lynch, David and Ware, Carl and Green, Douglas} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/14324"> <dc:contributor>LaFace, Drake</dc:contributor> <dc:contributor>Brunner, Thomas</dc:contributor> <dc:contributor>Echeverri, Fernando</dc:contributor> <dc:creator>Mahboubi, Artin</dc:creator> <dc:creator>Green, Douglas</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14324"/> <dc:contributor>Lynch, David</dc:contributor> <dc:rights>deposit-license</dc:rights> <dc:creator>LaFace, Drake</dc:creator> <dc:creator>Echeverri, Fernando</dc:creator> <dc:contributor>Yoo, Nam Jin</dc:contributor> <dc:contributor>Mahboubi, Artin</dc:contributor> <dc:creator>Yoo, Nam Jin</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Ware, Carl</dc:creator> <dc:creator>Mogil, Rona</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-17T09:05:26Z</dc:date> <dcterms:bibliographicCitation>Publ. in: Nature 373 (1995), 6513, pp. 441-444</dcterms:bibliographicCitation> <dc:language>eng</dc:language> <dc:creator>Lynch, David</dc:creator> <dcterms:abstract>A number of murine T-cell hybridomas undergo apoptosis within a few hours of activation by specific antigens, mitogens, antibodies against the T-cell antigen receptor, or a combination of phorbol ester and calcium ionophore. This phenomenon has been extensively studied as a model for clonal deletion in the immune system, in which potentially autoreactive T cells eliminate themselves by apoptosis after activation, either in the thymus or in the periphery. Here we show that the Fas/CD95 receptor, which can transduce a potent apoptotic signal when ligand, is rapidly expressed following activation of T-cell hybridomas, as is its functional, membrane-bound ligand. Interference with the ensuing Fas/Fas-ligand interaction inhibits activation-induced apoptosis. Because T-cell receptor ligation can induce apoptosis in a single T hybridoma cell, we suggest that the Fas/Fas-ligand interaction can induce cell death in a cell-autonomous manner.</dcterms:abstract> <dc:creator>Brunner, Thomas</dc:creator> <dc:creator>Martin, Seamus</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-17T09:05:26Z</dcterms:available> <dc:creator>Force, Walker</dc:creator> <dc:contributor>Force, Walker</dc:contributor> <dcterms:issued>1995-02-02</dcterms:issued> <dcterms:title>Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T cell hybridomas</dcterms:title> <dc:contributor>Martin, Seamus</dc:contributor> <dc:contributor>Green, Douglas</dc:contributor> <dc:contributor>Ware, Carl</dc:contributor> <dc:contributor>Mogil, Rona</dc:contributor> </rdf:Description> </rdf:RDF>

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