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IgE-independent interleukin-4 expression and induction of a late phase of leukotriene C4 formation in human blood basophils

IgE-independent interleukin-4 expression and induction of a late phase of leukotriene C4 formation in human blood basophils

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Prüfsumme: MD5:230fab0980a0ac5596da369754e50ee1

OCHENSBERGER, Brigitte, Silvia RIHS, Thomas BRUNNER, Clemens A. DAHINDEN, 1995. IgE-independent interleukin-4 expression and induction of a late phase of leukotriene C4 formation in human blood basophils. In: Blood. 86(11), pp. 4039-4049. ISSN 0006-4971. eISSN 1528-0020

@article{Ochensberger1995IgE-i-14317, title={IgE-independent interleukin-4 expression and induction of a late phase of leukotriene C4 formation in human blood basophils}, year={1995}, number={11}, volume={86}, issn={0006-4971}, journal={Blood}, pages={4039--4049}, author={Ochensberger, Brigitte and Rihs, Silvia and Brunner, Thomas and Dahinden, Clemens A.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/14317"> <dc:creator>Ochensberger, Brigitte</dc:creator> <dc:creator>Rihs, Silvia</dc:creator> <dc:rights>deposit-license</dc:rights> <dc:contributor>Rihs, Silvia</dc:contributor> <dcterms:issued>1995</dcterms:issued> <dcterms:abstract xml:lang="eng">T-helper cells can differentiate into at least two subtypes secreting distinct profiles of cytokines, Th1 and Th2, regulating immunoprotection and different immunopathologies. Interleukin-4 (IL-4) is both the product and the inducer of Th2 cells, raising the question whether IL-4 can be produced in response to antigen-independent stimuli. Here we show that human basophils produce IL-4 on stimulation with IL-3 and C5a or C5adesarg in similar amounts as induced by IgE- receptor-cross-linking. C5a-induced IL-4 production requires the presence of IL-3, with little effect of the sequence of stimuli addition. No “Th1-cytokines” (interferon-gamma and IL-2) and even no “Th2-cytokines” (IL-3, IL-5, IL-10, and granulocyte-macrophage colony- stimulating factor) are produced by basophils in response to either IgE- dependent or IgE-independent activation. The generation of leukotriene C4 (LTC4) is regulated in a similar manner. However, C5a induces a rapid, transient burst of leukotriene formation only if added after IL- 3. Interestingly, upon prolonged culture, a late phase of continuous LTC4 production is observed, which also requires two signals (IL-3 and C5a), but rather depends on their continuous presence than on their sequence of action. These data describe an antigen-independent pathway of very restricted IL-4 expression. Thus, basophils must be considered as central immunoregulatory cells of the innate immune system. Furthermore, the results show that LTC4 can also be generated more continuously for many hours, a phenomenon that may be of particular importance in chornic allergic inflammation, such as asthma.</dcterms:abstract> <dc:contributor>Brunner, Thomas</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14317"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-07-29T08:09:12Z</dcterms:available> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-07-29T08:09:12Z</dc:date> <dcterms:title>IgE-independent interleukin-4 expression and induction of a late phase of leukotriene C4 formation in human blood basophils</dcterms:title> <dc:creator>Dahinden, Clemens A.</dc:creator> <dc:creator>Brunner, Thomas</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:language>eng</dc:language> <dc:contributor>Ochensberger, Brigitte</dc:contributor> <dcterms:bibliographicCitation>First publ. in: Blood ; 86 (1995), 11. - pp. 4039-4049</dcterms:bibliographicCitation> <dc:contributor>Dahinden, Clemens A.</dc:contributor> </rdf:Description> </rdf:RDF>

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