KOPS - Das Institutionelle Repositorium der Universität Konstanz

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors : Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors : Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:ca2dd0f8aac846cd1dc2ccf68e3fc909

ZHANG, Xiaohong, Thomas BRUNNER, Laura CARTER, Richard W. DUTTON, Paul ROGERS, Linda BRADLEY, Takaaki SATO, John C. REED, Douglas GREEN, Susan L. SWAIN, 1997. Unequal Death in T Helper Cell (Th)1 and Th2 Effectors : Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis. In: Journal of Experimental Medicine. 185(10), pp. 1837-1849. ISSN 0022-1007

@article{Zhang1997Unequ-14313, title={Unequal Death in T Helper Cell (Th)1 and Th2 Effectors : Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis}, year={1997}, doi={10.1084/jem.185.10.1837}, number={10}, volume={185}, issn={0022-1007}, journal={Journal of Experimental Medicine}, pages={1837--1849}, author={Zhang, Xiaohong and Brunner, Thomas and Carter, Laura and Dutton, Richard W. and Rogers, Paul and Bradley, Linda and Sato, Takaaki and Reed, John C. and Green, Douglas and Swain, Susan L.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/14313"> <dc:contributor>Brunner, Thomas</dc:contributor> <dc:creator>Dutton, Richard W.</dc:creator> <dc:contributor>Bradley, Linda</dc:contributor> <dc:contributor>Swain, Susan L.</dc:contributor> <dc:contributor>Rogers, Paul</dc:contributor> <dcterms:abstract xml:lang="eng">T helper cell (Th) 1, but not Th2, effectors undergo rapid Fas/Fas ligand (FasL)-mediated, activation-induced cell death upon restimulation with antigen. Unequal apoptosis is also observed without restimulation, after a longer lag period. Both effectors undergo delayed apoptosis induced by a non–Fas-mediated pathway. When Th1 and Th2 effectors are co-cultured, Th2 effectors survive preferentially, suggesting the responsible factor(s) is intrinsic to each population. Both Th1 and Th2 effectors express Fas and FasL, but only Th2 effectors express high levels of FAP-1, a Fas-associated phosphatase that may act to inhibit Fas signaling. The rapid death of Th1 effectors leading to selective Th2 survival provides a novel mechanism for differential regulation of the two subsets.</dcterms:abstract> <dcterms:issued>1997</dcterms:issued> <dc:language>eng</dc:language> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-16T08:04:02Z</dc:date> <dc:creator>Reed, John C.</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14313"/> <dcterms:bibliographicCitation>First publ. in: Journal of Experimental Medicine ; 185 (1997), 10. - pp. 1837-1849</dcterms:bibliographicCitation> <dc:contributor>Dutton, Richard W.</dc:contributor> <dc:contributor>Carter, Laura</dc:contributor> <dc:contributor>Green, Douglas</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Bradley, Linda</dc:creator> <dc:creator>Green, Douglas</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-16T08:04:02Z</dcterms:available> <dc:creator>Brunner, Thomas</dc:creator> <dc:contributor>Zhang, Xiaohong</dc:contributor> <dcterms:title>Unequal Death in T Helper Cell (Th)1 and Th2 Effectors : Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis</dcterms:title> <dc:creator>Sato, Takaaki</dc:creator> <dc:creator>Swain, Susan L.</dc:creator> <dc:creator>Zhang, Xiaohong</dc:creator> <dc:creator>Carter, Laura</dc:creator> <dc:contributor>Sato, Takaaki</dc:contributor> <dc:contributor>Reed, John C.</dc:contributor> <dc:creator>Rogers, Paul</dc:creator> <dc:rights>deposit-license</dc:rights> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

1997_Zhang_Unequal Death in T Helper cell.pdf 86

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto