@article{Wasem2001Accum-14295,
  year={2001},
  doi={10.4049/​jimmunol.167.5.2936},
  title={Accumulation and activation-induced release of preformed Fas (CD95) ligand during the pathogenesis of experimental graft-versus-host disease},
  number={5},
  volume={167},
  issn={0022-1767},
  journal={Journal of Immunology},
  pages={2936--2941},
  author={Wasem, Christoph and Frutschi, Corina and Arnold, Diana and Vallan, Claudio and Lin, Tesu and Green, Douglas R. and Mueller, Christoph and Brunner, Thomas}
}

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    <dc:contributor>Lin, Tesu</dc:contributor>
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    <dc:creator>Arnold, Diana</dc:creator>
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    <dc:creator>Frutschi, Corina</dc:creator>
    <dc:contributor>Green, Douglas R.</dc:contributor>
    <dc:contributor>Frutschi, Corina</dc:contributor>
    <dc:creator>Mueller, Christoph</dc:creator>
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    <dcterms:abstract xml:lang="eng">Fas (CD95/APO-1) ligand (FasL)-mediated cytotoxicity has been implicated in tissue destruction in a variety of diseases, including acute graft-vs-host disease (GVHD). In this study, we have analyzed FasL expression and regulation during the course of experimental murine acute GVHD. Although activation-induced FasL-mediated cytotoxicity in control T cells was sensitive to the immunosuppressant cyclosporin A, we observed that functional FasL expression of GVHD T cells became increasingly cyclosporin A unresponsive. This was found to be the result of a massive in vivo accumulation and intracellular storage of FasL protein and its release in a transcription- and protein synthesis-independent manner. Immunohistochemistry analysis of FasL expression in situ revealed accumulation of FasL-expressing cells in the spleen, the liver, and small intestine, with a typical cytoplasmic and granular expression pattern. Thus, we conclude that the release of preformed FasL by infiltrating donor T cells may contribute to recipient tissue damage during the pathogenesis of acute GVHD.</dcterms:abstract>
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    <dc:contributor>Mueller, Christoph</dc:contributor>
    <dc:creator>Brunner, Thomas</dc:creator>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-21T12:42:22Z</dc:date>
    <dcterms:title>Accumulation and activation-induced release of preformed Fas (CD95) ligand during the pathogenesis of experimental graft-versus-host disease</dcterms:title>
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    <dc:contributor>Vallan, Claudio</dc:contributor>
    <dc:creator>Green, Douglas R.</dc:creator>
    <dc:contributor>Wasem, Christoph</dc:contributor>
    <dcterms:bibliographicCitation>First publ. in: Journal of Immunology ; 167 (2001), 5. - S. 2936-2941</dcterms:bibliographicCitation>
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    <dc:contributor>Brunner, Thomas</dc:contributor>
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