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Effects of antiretroviral drugs on human immunodeficiency virus type 1-induced CD4(+) T-cell death

Effects of antiretroviral drugs on human immunodeficiency virus type 1-induced CD4(+) T-cell death

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ESTAQUIER, Jérôme, Jean-Daniel LELIÈVRE, Frédéric PETIT, Thomas BRUNNER, Laure MOUTOUH-DE PARSEVAL, Douglas D. RICHMAN, Jean Claude AMEISEN, Jacques CORBEIL, 2002. Effects of antiretroviral drugs on human immunodeficiency virus type 1-induced CD4(+) T-cell death. In: Journal of Virology. 76(12), pp. 5966-5973. ISSN 0022-538X

@article{Estaquier2002Effec-14291, title={Effects of antiretroviral drugs on human immunodeficiency virus type 1-induced CD4(+) T-cell death}, year={2002}, doi={10.1128/JVI.76.12.5966-5973.2002}, number={12}, volume={76}, issn={0022-538X}, journal={Journal of Virology}, pages={5966--5973}, author={Estaquier, Jérôme and Lelièvre, Jean-Daniel and Petit, Frédéric and Brunner, Thomas and Moutouh-de Parseval, Laure and Richman, Douglas D. and Ameisen, Jean Claude and Corbeil, Jacques} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/14291"> <dcterms:issued>2002</dcterms:issued> <dc:language>eng</dc:language> <dc:creator>Brunner, Thomas</dc:creator> <dc:contributor>Petit, Frédéric</dc:contributor> <dcterms:abstract xml:lang="eng">Apoptosis of peripheral blood T cells plays an important role in the pathogenesis of human immunodeficiency virus (HIV) infection. In this study, we found that HIV type 1 (HIV-1) primes CD4+ T cells from healthy donors for apoptosis, which occurs after CD95 ligation or CD3-T-cell receptor (TCR) stimulation. CD95-mediated death did not depend on CD4 T-cell infection, since it occurred in the presence of the reverse transcriptase inhibitor didanosine (ddI). In contrast, apoptosis induced by productive infection (CD3-TCR stimulation) is prevented by both CD95 decoy receptor and ddI. Our data suggest that HIV-1 triggers at least two distinct death pathways: a CD95-dependent pathway that does not require viral replication and a viral replication-mediated cell death independent of the CD95 pathway. Further experiments indicated that saquinavir, a protease inhibitor, at a 0.2 µM concentration, decreased HIV-mediated CD95 expression and thus cell death, which is independent of its role in inhibiting viral replication. However, treatment of peripheral blood mononuclear cells from healthy donors with a higher concentration (10 µM) of an HIV protease inhibitor, saquinavir or indinavir, induced both a loss in mitochondrial membrane potential ({Delta}{Psi}m) and cell death. Thus, protease inhibitors have the potential for both beneficial and detrimental effects on CD4+ T cells independent of their antiretroviral effects.</dcterms:abstract> <dc:creator>Ameisen, Jean Claude</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14291"/> <dc:contributor>Estaquier, Jérôme</dc:contributor> <dc:contributor>Brunner, Thomas</dc:contributor> <dc:creator>Moutouh-de Parseval, Laure</dc:creator> <dc:creator>Richman, Douglas D.</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-21T08:19:02Z</dc:date> <dc:creator>Petit, Frédéric</dc:creator> <dc:contributor>Moutouh-de Parseval, Laure</dc:contributor> <dc:creator>Lelièvre, Jean-Daniel</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-21T08:19:02Z</dcterms:available> <dcterms:title>Effects of antiretroviral drugs on human immunodeficiency virus type 1-induced CD4(+) T-cell death</dcterms:title> <dc:contributor>Richman, Douglas D.</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Corbeil, Jacques</dc:creator> <dc:contributor>Ameisen, Jean Claude</dc:contributor> <dc:contributor>Corbeil, Jacques</dc:contributor> <dcterms:bibliographicCitation>First publ. in: Journal of Virology ; 76 (2002), 12. - S. 5966-5973</dcterms:bibliographicCitation> <dc:creator>Estaquier, Jérôme</dc:creator> <dc:contributor>Lelièvre, Jean-Daniel</dc:contributor> <dc:rights>deposit-license</dc:rights> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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