KOPS - The Institutional Repository of the University of Konstanz

The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine

The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine

Cite This

Files in this item

Checksum: MD5:1e731197336a1a6a24d2fba5e6e0c810

MÜLLER, Matthias, Igor CIMA, Mario NOTI, Andrea FUHRER, Sabine JAKOB, Laurent DUBUQUOY, Kristina SCHOONJANS, Thomas BRUNNER, 2006. The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine. In: Journal of Experimental Medicine. 203(9), pp. 2057-2062. ISSN 0022-1007. Available under: doi: 10.1084/jem.20060357

@article{Muller2006-09-04nucle-14278, title={The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine}, year={2006}, doi={10.1084/jem.20060357}, number={9}, volume={203}, issn={0022-1007}, journal={Journal of Experimental Medicine}, pages={2057--2062}, author={Müller, Matthias and Cima, Igor and Noti, Mario and Fuhrer, Andrea and Jakob, Sabine and Dubuquoy, Laurent and Schoonjans, Kristina and Brunner, Thomas} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/14278"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-13T09:30:59Z</dc:date> <dc:creator>Brunner, Thomas</dc:creator> <dc:creator>Cima, Igor</dc:creator> <dc:contributor>Jakob, Sabine</dc:contributor> <dc:contributor>Fuhrer, Andrea</dc:contributor> <dc:contributor>Dubuquoy, Laurent</dc:contributor> <dc:creator>Müller, Matthias</dc:creator> <dc:contributor>Cima, Igor</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14278/2/2006_Mueller_The%20nuclear%20receptor%20LRH1.pdf"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Schoonjans, Kristina</dc:contributor> <dc:contributor>Brunner, Thomas</dc:contributor> <dcterms:rights rdf:resource="https://kops.uni-konstanz.de/page/termsofuse"/> <dcterms:issued>2006-09-04</dcterms:issued> <dc:creator>Schoonjans, Kristina</dc:creator> <dc:creator>Fuhrer, Andrea</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Jakob, Sabine</dc:creator> <dc:contributor>Müller, Matthias</dc:contributor> <dc:creator>Dubuquoy, Laurent</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14278/2/2006_Mueller_The%20nuclear%20receptor%20LRH1.pdf"/> <dcterms:title>The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine</dcterms:title> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-13T09:30:59Z</dcterms:available> <dcterms:bibliographicCitation>First Publ. in: The journal of experimental medicine : JEM ; 203 (2006), 9. - pp. 2057-2062</dcterms:bibliographicCitation> <dcterms:abstract>The nuclear receptor liver receptor homologue-1 (LRH-1, NR5A2) is a crucial transcriptional regulator of many metabolic pathways. In addition, LRH-1 is expressed in intestinal crypt cells where it regulates the epithelial cell renewal and contributes to tumorigenesis through the induction of cell cycle proteins. We have recently identified the intestinal epithelium as an important extra-adrenal source of immunoregulatory glucocorticoids. We show here that LRH-1 promotes the expression of the steroidogenic enzymes and the synthesis of corticosterone in murine intestinal epithelial cells in vitro. Interestingly, LRH-1 is also essential for intestinal glucocorticoid synthesis in vivo, as LRH-1 haplo-insufficiency strongly reduces the intestinal expression of steroidogenic enzymes and glucocorticoid synthesis upon immunological stress. These results demonstrate for the first time a novel role for LRH-1 in the regulation of intestinal glucocorticoid synthesis and propose LRH-1 as an important regulator of intestinal tissue integrity and immune homeostasis.</dcterms:abstract> <dc:language>eng</dc:language> <dc:contributor>Noti, Mario</dc:contributor> <dc:creator>Noti, Mario</dc:creator> <dc:rights>terms-of-use</dc:rights> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14278"/> </rdf:Description> </rdf:RDF>

Downloads since Oct 1, 2014 (Information about access statistics)

2006_Mueller_The nuclear receptor LRH1.pdf 297

This item appears in the following Collection(s)

Search KOPS


Browse

My Account