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LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

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Prüfsumme: MD5:170830963eff9a0ef4225cdd28d2b2f6

COSTE, Agnes, Laurent DUBUQUOY, Romain BARNOUIN, Jean-Sebastien ANNICOTTE, Benjamin MAGNIER, Mario NOTTI, Nadia CORAZZA, Maria Cristina ANTAL, Daniel METZGER, Pierre DESREUMAUX, Thomas BRUNNER, Johan AUWERX, Kristina SCHOONJANS, 2007. LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease. In: Proceedings of the National Academy of Sciences. 104(32), pp. 13098-13103. ISSN 0027-8424

@article{Coste2007-08-07LRH-1-14272, title={LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease}, year={2007}, doi={10.1073/pnas.0702440104}, number={32}, volume={104}, issn={0027-8424}, journal={Proceedings of the National Academy of Sciences}, pages={13098--13103}, author={Coste, Agnes and Dubuquoy, Laurent and Barnouin, Romain and Annicotte, Jean-Sebastien and Magnier, Benjamin and Notti, Mario and Corazza, Nadia and Antal, Maria Cristina and Metzger, Daniel and Desreumaux, Pierre and Brunner, Thomas and Auwerx, Johan and Schoonjans, Kristina} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/14272"> <dc:contributor>Brunner, Thomas</dc:contributor> <dcterms:bibliographicCitation>First publ. in: Proceedings of the National Academy of Sciences of the United States of America : PNAS ; 104 (2007), 32. - pp. 13098-13103</dcterms:bibliographicCitation> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-19T14:08:10Z</dc:date> <dc:creator>Metzger, Daniel</dc:creator> <dc:contributor>Notti, Mario</dc:contributor> <dc:contributor>Annicotte, Jean-Sebastien</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Antal, Maria Cristina</dc:creator> <dc:contributor>Barnouin, Romain</dc:contributor> <dc:creator>Corazza, Nadia</dc:creator> <dc:creator>Coste, Agnes</dc:creator> <dc:creator>Barnouin, Romain</dc:creator> <dcterms:issued>2007-08-07</dcterms:issued> <dc:contributor>Desreumaux, Pierre</dc:contributor> <dc:rights>deposit-license</dc:rights> <dc:creator>Annicotte, Jean-Sebastien</dc:creator> <dc:contributor>Auwerx, Johan</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14272"/> <dc:contributor>Coste, Agnes</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-19T14:08:10Z</dcterms:available> <dc:creator>Notti, Mario</dc:creator> <dcterms:title>LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease</dcterms:title> <dc:contributor>Dubuquoy, Laurent</dc:contributor> <dc:contributor>Metzger, Daniel</dc:contributor> <dc:creator>Schoonjans, Kristina</dc:creator> <dc:creator>Desreumaux, Pierre</dc:creator> <dc:contributor>Magnier, Benjamin</dc:contributor> <dcterms:abstract xml:lang="eng">Liver receptor homolog-1 (LRH-1) is a nuclear receptor involved in intestinal lipid homeostasis and cell proliferation. Here we show that haploinsufficiency of LRH-1 predisposes mice to the development of intestinal inflammation. Besides the increased inflammatory response, LRH-1 heterozygous mice exposed to 2,4,6-trinitrobenzene sulfonic acid show lower local corticosterone production as a result of an impaired intestinal expression of the enzymes CYP11A1 and CYP11B1, which control the local synthesis of corticosterone in the intestine. Local glucocorticoid production is strictly enterocytedependent because it is robustly reduced in epithelium-specific LRH-1-deficient mice. Consistent with these findings, colon biopsies of patients with Crohn’s disease and ulcerative colitis show reduced expression of LRH-1 and genes involved in the production of glucocorticoids. Hence, LRH-1 regulates intestinal immunity in response to immunological stress by triggering local glucocorticoid production. These findings underscore the importance of LRH-1 in the control of intestinal inflammation and the pathogenesis of inflammatory bowel disease. v</dcterms:abstract> <dc:creator>Brunner, Thomas</dc:creator> <dc:contributor>Antal, Maria Cristina</dc:contributor> <dc:creator>Auwerx, Johan</dc:creator> <dc:creator>Magnier, Benjamin</dc:creator> <dc:contributor>Corazza, Nadia</dc:contributor> <dc:creator>Dubuquoy, Laurent</dc:creator> <dc:language>eng</dc:language> <dc:contributor>Schoonjans, Kristina</dc:contributor> </rdf:Description> </rdf:RDF>

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