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Active caspase 3 and DNA fragmentation as markers for apoptotic cell death in primary and metastatic liver tumours

Active caspase 3 and DNA fragmentation as markers for apoptotic cell death in primary and metastatic liver tumours

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KARAMITOPOULOU, Eva, Luca CIOCCARI, Sabine JAKOB, Claudio VALLAN, Thomas SCHAFFNER, Arthur ZIMMERMANN, Thomas BRUNNER, 2007. Active caspase 3 and DNA fragmentation as markers for apoptotic cell death in primary and metastatic liver tumours. In: Pathology. 39(6), pp. 558-564. ISSN 1465-3931

@article{Karamitopoulou2007-12Activ-14271, title={Active caspase 3 and DNA fragmentation as markers for apoptotic cell death in primary and metastatic liver tumours}, year={2007}, doi={10.1080/00313020701684375}, number={6}, volume={39}, issn={1465-3931}, journal={Pathology}, pages={558--564}, author={Karamitopoulou, Eva and Cioccari, Luca and Jakob, Sabine and Vallan, Claudio and Schaffner, Thomas and Zimmermann, Arthur and Brunner, Thomas} }

Karamitopoulou, Eva Jakob, Sabine Schaffner, Thomas Jakob, Sabine 2007-12 Brunner, Thomas 2011-10-19T13:53:30Z 2011-10-19T13:53:30Z Brunner, Thomas Cioccari, Luca Vallan, Claudio Publ. in: Pathology ; 39 (2007), 6. - pp. 558–564 Karamitopoulou, Eva Cioccari, Luca deposit-license Active caspase 3 and DNA fragmentation as markers for apoptotic cell death in primary and metastatic liver tumours Zimmermann, Arthur Zimmermann, Arthur Schaffner, Thomas eng Aims: The induction of tumour cell death by apoptosis is a<br />major goal of cancer therapy and the in situ detection of<br />apoptosis in tumour tissue has become an important<br />diagnostic parameter. Different apoptosis detection methods<br />assess distinct biochemical processes in the dying cell. Thus,<br />their direct comparison is mandatory to evaluate their<br />diagnostic value. The aim of this study was to compare the<br />immunohistochemical detection of active caspase 3 and<br />single-stranded DNA in primary and metastatic liver tumours<br />as markers of apoptotic cell death.<br />Methods: We studied detection of active caspase 3 and<br />single-stranded DNA in 20 primary hepatocellular carcinomas<br />(HCC) and 20 liver metastases from colorectal<br />carcinomas (CRC) using immunohistochemistry on paraffin<br />sections.<br />Results: Our results reveal that both methods are suitable<br />and sensitive techniques for the in situ detection of<br />apoptosis, however, they also demonstrate that immunohistochemistry<br />for active caspase 3 and single-stranded DNA<br />have differential sensitivities in HCC and CRC.<br />Conclusion: The sensitivity of apoptosis detection using<br />immunohistochemistry for active caspase 3 and singlestranded<br />DNA may be tumour cell type dependent. Vallan, Claudio

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