KOPS - Das Institutionelle Repositorium der Universität Konstanz

Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer : a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas

Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer : a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:28f075969c3ae432f56fb9dec6b89822

KARAMITOPOULOU, Eva, Luigi TORNILLO, Inti ZLOBEC, Lukas CIOCCARI, Vincenza CARAFA, Markus BORNER, Thomas SCHAFFNER, Thomas BRUNNER, Ioannis DIAMANTIS, Arthur ZIMMERMANN, Luigi TERRACCIANO, 2008. Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer : a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas. In: American Journal of Clinical Pathology. 130(5), pp. 780-786. ISSN 0002-9173. eISSN 1943-7722. Available under: doi: 10.1309/AJCP35FDCAVANWMM

@article{Karamitopoulou2008-11Clini-14263, title={Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer : a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas}, year={2008}, doi={10.1309/AJCP35FDCAVANWMM}, number={5}, volume={130}, issn={0002-9173}, journal={American Journal of Clinical Pathology}, pages={780--786}, author={Karamitopoulou, Eva and Tornillo, Luigi and Zlobec, Inti and Cioccari, Lukas and Carafa, Vincenza and Borner, Markus and Schaffner, Thomas and Brunner, Thomas and Diamantis, Ioannis and Zimmermann, Arthur and Terracciano, Luigi} }

Diamantis, Ioannis 2011-10-19T08:59:39Z Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer : a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas eng First publ. in: American Journal of Clinical Pathology ; 130 (2008), 5. - pp. 780-786 Schaffner, Thomas Brunner, Thomas Cioccari, Lukas deposit-license Diamantis, Ioannis 2008-11 Zlobec, Inti Terracciano, Luigi Tornillo, Luigi Terracciano, Luigi Cioccari, Lukas Schaffner, Thomas Karamitopoulou, Eva 2011-10-19T08:59:39Z Carafa, Vincenza Borner, Markus Zimmermann, Arthur Carafa, Vincenza Tornillo, Luigi Karamitopoulou, Eva Zimmermann, Arthur Zlobec, Inti Brunner, Thomas Borner, Markus Cholangiocarcinoma is the second most common malignant tumor of the liver. We analyzed, immunohistochemically, the significance of cell cycle– and apoptosis-related markers in 128 cholangiocarcinomas (42 intrahepatic, 70 extrahepatic, and 16 gallbladder carcinomas) combined in a tissue microarray. Follow-up was available for 57 patients (44.5%). In comparison with normal tissue (29 specimens), cholangiocarcinomas expressed significantly more frequently p53, bcl-2, bax, and COX-2 (P < .05). Intrahepatic tumors were significantly more frequently bcl-2+ and p16+, whereas extrahepatic tumors were more often p53+ (P < .05). Loss of p16 expression was associated with reduced survival of patients. Our data show that p53, bcl-2, bax, and COX-2 have an important role in the pathogenesis of cholangiocarcinomas. The differential expression of p16, bcl-2, and p53 between intrahepatic and extrahepatic tumors demonstrates that there are location-related differences in the phenotype and the genetic profiles of these tumors. Moreover, p16 was identified as an important prognostic marker in cholangiocarcinomas.

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

2008_Karamitopoulou_AJCP_08.pdf 216

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto