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Soluble TNF-α but not transmembrane TNF-α sensitizes T cells for enhanced activation-induced cell death

Soluble TNF-α but not transmembrane TNF-α sensitizes T cells for enhanced activation-induced cell death

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Prüfsumme: MD5:80eb46b025a494debb8f9af4a87a604d

MÜLLER, Stefan, Silvia RIHS, Johanna M. DAYER SCHNEIDER, Bruno E. PAREDES, Ingeborg SEIBOLD, Thomas BRUNNER, Christoph MUELLER, 2009. Soluble TNF-α but not transmembrane TNF-α sensitizes T cells for enhanced activation-induced cell death. In: European Journal of Immunology. 39(11), pp. 3171-3180. ISSN 0014-2980. eISSN 1521-4141

@article{Muller2009-11Solub-14256, title={Soluble TNF-α but not transmembrane TNF-α sensitizes T cells for enhanced activation-induced cell death}, year={2009}, doi={10.1002/eji.200939554}, number={11}, volume={39}, issn={0014-2980}, journal={European Journal of Immunology}, pages={3171--3180}, author={Müller, Stefan and Rihs, Silvia and Dayer Schneider, Johanna M. and Paredes, Bruno E. and Seibold, Ingeborg and Brunner, Thomas and Mueller, Christoph} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/14256"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-07-29T10:13:08Z</dc:date> <dc:creator>Müller, Stefan</dc:creator> <dc:creator>Brunner, Thomas</dc:creator> <dc:contributor>Rihs, Silvia</dc:contributor> <dc:language>eng</dc:language> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-07-29T10:13:08Z</dcterms:available> <dc:rights>deposit-license</dc:rights> <dc:creator>Dayer Schneider, Johanna M.</dc:creator> <dc:creator>Seibold, Ingeborg</dc:creator> <dc:creator>Paredes, Bruno E.</dc:creator> <dc:contributor>Paredes, Bruno E.</dc:contributor> <dc:contributor>Seibold, Ingeborg</dc:contributor> <dc:contributor>Brunner, Thomas</dc:contributor> <dcterms:issued>2009-11</dcterms:issued> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14256"/> <dc:contributor>Dayer Schneider, Johanna M.</dc:contributor> <dc:creator>Mueller, Christoph</dc:creator> <dcterms:bibliographicCitation>Publ. in: European Journal of Immunology ; 39 (2009), 11. - pp. 3171-3180</dcterms:bibliographicCitation> <dc:contributor>Müller, Stefan</dc:contributor> <dcterms:title>Soluble TNF-α but not transmembrane TNF-α sensitizes T cells for enhanced activation-induced cell death</dcterms:title> <dc:contributor>Mueller, Christoph</dc:contributor> <dcterms:abstract xml:lang="eng">In addition to its proinflammatory effects, TNF-α exhibits immunosuppression. Here, we compared the capacities of transmembrane TNF-α (tmTNF) and soluble TNF-α (sTNF) in regulating expansion of activated T cells by apoptosis. Splenic CD4+ T cells from wtTNF, TNF-α-deficient (TNF−/−) and TNF−/− mice expressing a non-cleavable mutant tmTNF showed comparable proliferation rates upon TCR-mediated stimulation. Activation-induced cell death (AICD), however, was significantly attenuated in tmTNF and TNF−/−, compared with wtTNF CD4+ T cells. Addition of sTNF during initial priming was sufficient to enhance susceptibility to AICD in tmTNF and TNF−/− CD4+ T cells to levels seen in wtTNF CD4+ T cells, whereas addition of sTNF only during restimulation failed to enhance AICD. sTNF-induced, enhanced susceptibility to AICD was dependent on both TNF receptors. The reduced susceptibility of tmTNF CD4+ T cells for AICD was also evident in an in vivo model of adoptively transferred CD4+ T-cell-mediated colonic inflammation. Hence, the presence of sTNF during T-cell priming may represent an important mechanism to sensitize activated T cells for apoptosis, thereby attenuating the extent and duration of T-cell reactivities and subsequent T-cell-mediated, excessive inflammation.</dcterms:abstract> <dc:creator>Rihs, Silvia</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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