KOPS - The Institutional Repository of the University of Konstanz

HR22C16 : a potent small-molecule probe for the dynamics of cell division

HR22C16 : a potent small-molecule probe for the dynamics of cell division

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

HOTHA, Srinivas, Justin C. YARROW, Janet G. YANG, Sarah GARRETT, Kishore V. RENDUCHINTALA, Thomas MAYER, Tarun M. KAPOOR, 2003. HR22C16 : a potent small-molecule probe for the dynamics of cell division. In: Angewandte Chemie International Edition. 42(21), pp. 2379-2382. ISSN 1433-7851. Available under: doi: 10.1002/anie.200351173

@article{Hotha2003-05-30HR22C-14051, title={HR22C16 : a potent small-molecule probe for the dynamics of cell division}, year={2003}, doi={10.1002/anie.200351173}, number={21}, volume={42}, issn={1433-7851}, journal={Angewandte Chemie International Edition}, pages={2379--2382}, author={Hotha, Srinivas and Yarrow, Justin C. and Yang, Janet G. and Garrett, Sarah and Renduchintala, Kishore V. and Mayer, Thomas and Kapoor, Tarun M.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/14051"> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Kapoor, Tarun M.</dc:creator> <dcterms:issued>2003-05-30</dcterms:issued> <dc:contributor>Hotha, Srinivas</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-01-11T10:40:18Z</dcterms:available> <dcterms:bibliographicCitation>Ersch. in: Angewandte Chemie / Internaional Edition ; 42 (2003), 21. - S. 2379-2382.</dcterms:bibliographicCitation> <dc:creator>Yang, Janet G.</dc:creator> <dc:contributor>Mayer, Thomas</dc:contributor> <dc:contributor>Yarrow, Justin C.</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Renduchintala, Kishore V.</dc:creator> <dc:contributor>Kapoor, Tarun M.</dc:contributor> <dc:contributor>Renduchintala, Kishore V.</dc:contributor> <dc:creator>Garrett, Sarah</dc:creator> <dc:creator>Mayer, Thomas</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-01-11T10:40:18Z</dc:date> <dc:language>eng</dc:language> <dc:creator>Hotha, Srinivas</dc:creator> <dcterms:title>HR22C16 : a potent small-molecule probe for the dynamics of cell division</dcterms:title> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Garrett, Sarah</dc:contributor> <dc:contributor>Yang, Janet G.</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Yarrow, Justin C.</dc:creator> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dcterms:abstract xml:lang="eng">A high-throughput, microscopy-based chemical-genetic screen identified HR22C16, which causes a monoastral mitotic block, as a small-molecule probe for cell division (see picture). By using a diastereoselective, traceless solid-phase synthesis and biological assays, a more potent HR22C16 analogue was then identified. A photocaging strategy for HR22C16 was also developed to allow fast temporal control over the function of the target protein Eg5.</dcterms:abstract> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14051"/> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

Search KOPS


Browse

My Account