Cytostatic factor : an activity that puts the cell cycle on hold


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SCHMIDT, Andreas, Nadine R. RAUH, Erich A. NIGG, Thomas MAYER, 2006. Cytostatic factor : an activity that puts the cell cycle on hold. In: Journal of Cell Science. 119(7), pp. 1213-1218. ISSN 0021-9533. Available under: doi: 10.1242/jcs.02919

@article{Schmidt2006-04-01Cytos-14043, title={Cytostatic factor : an activity that puts the cell cycle on hold}, year={2006}, doi={10.1242/jcs.02919}, number={7}, volume={119}, issn={0021-9533}, journal={Journal of Cell Science}, pages={1213--1218}, author={Schmidt, Andreas and Rauh, Nadine R. and Nigg, Erich A. and Mayer, Thomas} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:available rdf:datatype="">2012-01-11T09:09:48Z</dcterms:available> <dc:contributor>Mayer, Thomas</dc:contributor> <dc:creator>Nigg, Erich A.</dc:creator> <dc:contributor>Schmidt, Andreas</dc:contributor> <dc:creator>Mayer, Thomas</dc:creator> <dc:contributor>Nigg, Erich A.</dc:contributor> <dc:creator>Rauh, Nadine R.</dc:creator> <dcterms:hasPart rdf:resource=""/> <dspace:hasBitstream rdf:resource=""/> <dcterms:rights rdf:resource=""/> <dcterms:abstract xml:lang="eng">Fertilization is the fundamental process in which two gametes - sperm and oocyte - fuse to generate a zygote that will form a new multicellular organism. In most vertebrates, oocytes await fertilization while arrested at metaphase of meiosis II. This resting state can be stable for many hours and depends on a cytoplasmic activity termed cytostatic factor (CSF). Recently, members of the novel Emi/Erp family of proteins have been put forward as important components of CSF. These proteins inhibit the anaphase-promoting complex/cyclosome (APC/C), which acts at the very core of the cell cycle regulatory machinery. Initially, Xenopus early mitotic inhibitor 1 (Emi1) was proposed to be a component of CSF, but newer work suggests that a structural relative, Emi-related protein 1 (Erp1/Emi2), is essential for maintenance of CSF arrest in Xenopus. Most importantly, studies on Erp1/Emi2 regulation have led to a detailed molecular understanding of the Ca2+-mediated release from CSF arrest that occurs upon fertilization.</dcterms:abstract> <dcterms:title>Cytostatic factor : an activity that puts the cell cycle on hold</dcterms:title> <dc:date rdf:datatype="">2012-01-11T09:09:48Z</dc:date> <dc:rights>terms-of-use</dc:rights> <dcterms:issued>2006-04-01</dcterms:issued> <bibo:uri rdf:resource=""/> <dspace:isPartOfCollection rdf:resource=""/> <dcterms:isPartOf rdf:resource=""/> <dc:contributor>Rauh, Nadine R.</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:bibliographicCitation>First publ. in: Journal of Cell Science ; 119 (2006), 7. - S. 1213-1218</dcterms:bibliographicCitation> <dc:language>eng</dc:language> <dc:creator>Schmidt, Andreas</dc:creator> </rdf:Description> </rdf:RDF>

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