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Training-Induced Modification of Auditory Sensory Processing in Schizophrenia : Evidence from Event-Related and Time-Frequency Analysis

Training-Induced Modification of Auditory Sensory Processing in Schizophrenia : Evidence from Event-Related and Time-Frequency Analysis

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POPOV, Tzvetan, 2011. Training-Induced Modification of Auditory Sensory Processing in Schizophrenia : Evidence from Event-Related and Time-Frequency Analysis

@phdthesis{Popov2011Train-13947, title={Training-Induced Modification of Auditory Sensory Processing in Schizophrenia : Evidence from Event-Related and Time-Frequency Analysis}, year={2011}, author={Popov, Tzvetan}, address={Konstanz}, school={Universität Konstanz} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/13947"> <dcterms:abstract xml:lang="eng">Cognitive remediation plays an increasingly important role in schizophrenia treatment. Mixed results of significant improvement in cognitive performance and symptoms along with improvements in psychosocial functioning might be due to a focus on a broad-spectrum of cognitive abilities, rather than specific deficits such as verbal working memory and processing speed. Cognitive intervention benefits are often demonstrated on behavioral level, while evidence in support of associated cortical mechanisms remains elusive. The aim of the present thesis was to explore whether effects of cognitive training in schizophrenia become manifest not only in test performance and general functioning measures, but also on the level of cortical mechanisms contributing to these psychological functions. A novel cognitive intervention approach was evaluated, designed to address auditory-verbal discrimination accuracy, speed-up auditory processing and improve memory functions (CE, cognitive exercises). Study 1: The ratio of scalp-recorded evoked brain responses occurring 50 ms after paired clicks served as a measure of sensory gating. An abnormally high ratio is considered as a sign of dysfunctional organization of the auditory/verbal system and as a factor contributing to psychopathology and cognitive deficits in schizophrenia. MEG and performance on verbal learning and memory test were used for evaluation of training effects. Post treatment gating ratio decreased together with improvement in cognitive test-performance after appropriately specific psychological intervention (CE, cognitive exercises) compared to a standard computer-based cognitive training (CP, cognitive package). Study 2: Processes contributing to the phenomenon of altered M50 gating ratio were evaluated using event-related oscillations. Schizophrenia inpatients (n=50) showed the expected large M50 gating ratio relative to 48 healthy controls. In patients large gating ratio was correlated with less induced fronto-parietal generated activity in the 10-15 Hz frequency band starting 200 ms before the onset of the second stimulus in a pair. In addition, patients produced smaller alpha (8-12 Hz) and gamma (60-80 Hz) band responses to the first auditory stimulus. Results suggested that the deviant gating ratio in schizophrenia is a consequence of a complex alteraii tion in the processing of incoming information that cannot be attributed to filtering deficit alone. Study 3: Event-related oscillations together with M50 gating ratio were analyzed in a paired-stimulus design before and after 4-weeks of cognitive training in schizophrenia patients randomly assigned either to CE or CP. Prior to training patients differ from healthy control subjects by less induced alpha (8-12Hz) band power decrease preceding the second stimulus and smaller evoked gamma (60-80Hz) response to the first auditory stimulus together with higher-than-normal gating ratios. Both oscillatory activities increased after cognitive intervention in all schizophrenic subjects, though more so in patients participating in the auditory/verbal discrimination training (CE group). After CE the improvement in alpha band power decrease varied with the improvement in M50 ratio, verbal working memory and functional outcome, indicating training effects on mechanisms contributing to sensory gating and cognitive performance in schizophrenia.</dcterms:abstract> <dc:language>eng</dc:language> <dc:rights>deposit-license</dc:rights> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/13947"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-07-04T10:29:36Z</dcterms:available> <dc:contributor>Popov, Tzvetan</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:issued>2011</dcterms:issued> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-07-04T10:29:36Z</dc:date> <dcterms:title>Training-Induced Modification of Auditory Sensory Processing in Schizophrenia : Evidence from Event-Related and Time-Frequency Analysis</dcterms:title> <dc:creator>Popov, Tzvetan</dc:creator> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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