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Identification of Novel Quadruplex Ligands from Small Molecule Libraries by FRET-Based High-Throughput Screening

Identification of Novel Quadruplex Ligands from Small Molecule Libraries by FRET-Based High-Throughput Screening

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BENZ, Armin, Vijay SINGH, Thomas U. MAYER, Jörg S. HARTIG, 2011. Identification of Novel Quadruplex Ligands from Small Molecule Libraries by FRET-Based High-Throughput Screening. In: ChemBioChem. 12(9), pp. 1422-1426. ISSN 1439-4227. eISSN 1439-7633

@article{Benz2011-06-14Ident-13689, title={Identification of Novel Quadruplex Ligands from Small Molecule Libraries by FRET-Based High-Throughput Screening}, year={2011}, doi={10.1002/cbic.201100094}, number={9}, volume={12}, issn={1439-4227}, journal={ChemBioChem}, pages={1422--1426}, author={Benz, Armin and Singh, Vijay and Mayer, Thomas U. and Hartig, Jörg S.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/13689"> <dcterms:title>Identification of Novel Quadruplex Ligands from Small Molecule Libraries by FRET-Based High-Throughput Screening</dcterms:title> <dc:contributor>Mayer, Thomas U.</dc:contributor> <dc:creator>Benz, Armin</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/13689"/> <dc:creator>Mayer, Thomas U.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-17T07:33:07Z</dcterms:available> <dcterms:issued>2011-06-14</dcterms:issued> <dc:creator>Singh, Vijay</dc:creator> <dc:language>eng</dc:language> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:contributor>Benz, Armin</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-17T07:33:07Z</dc:date> <dcterms:bibliographicCitation>ChemBioChem ; 12 (2011), 9. - S. 1422-1426</dcterms:bibliographicCitation> <dc:contributor>Hartig, Jörg S.</dc:contributor> <dcterms:abstract xml:lang="eng">Guanosine-rich nucleic acid sequences can fold into noncanonical higher order structures named G quadruplexes (GQPs). These folds are stabilized by eight Hoogsteen hydrogen bonds per tetrad and p–p stacking interactions between the tetrads.[1] Due to their stability quadruplexes occurring in promoter regions of genes [2] or at the telomeric ends of eukaryotic chromosomes have been suspected to play regulatory roles in gene expression and cell cycle control. [3] In addition, compounds binding to quadruplexes have been studied intensively because of their potential in anticancer treatment.[4] Telomeric DNA comprises thousands of double-stranded tandem repeats of the sequence d(GGGTTA)[5] and a single stranded G rich 3’ overhang of about 100–200 nucleotides.[6] During the life time of a somatic cell telomeres are permanently shortened because of the end-replication problem. At a critical length this leads to induction of cell cycle arrest or even to cell death. [7] However, in about 80–85% of all cancer cells this problem is circumvented as the telomere length is maintained by activation of telomerase,[8] an enzyme that is inactive in somatic cells. [9] By addition of telomeric repeats to the single stranded 3’ overhang, cancer cells can become immortal.[10] Several compounds have been shown to induce quadruplexes, disturbing the telomeric structure and function providing a promising anticancer treatment.</dcterms:abstract> <dc:rights>deposit-license</dc:rights> <dc:contributor>Singh, Vijay</dc:contributor> <dc:creator>Hartig, Jörg S.</dc:creator> </rdf:Description> </rdf:RDF>

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