Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1

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HÖRMANSEDER, Eva, Thomas TISCHER, Simone HEUBES, Olaf STEMMANN, Thomas MAYER, 2011. Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1. In: EMBO reports. 12(5), pp. 436-443. ISSN 1469-221X. eISSN 1469-3178

@article{Hormanseder2011-05Non-p-13685, title={Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1}, year={2011}, doi={10.1038/embor.2011.32}, number={5}, volume={12}, issn={1469-221X}, journal={EMBO reports}, pages={436--443}, author={Hörmanseder, Eva and Tischer, Thomas and Heubes, Simone and Stemmann, Olaf and Mayer, Thomas} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/13685"> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:contributor>Hörmanseder, Eva</dc:contributor> <dcterms:abstract xml:lang="eng">Mature Xenopus oocytes are arrested in meiosis by the activity of XErp1/Emi2, an inhibitor of the ubiquitin-ligase anaphase-promoting complex/cyclosome (APC/C). On fertilization, XErp1 is degraded, resulting in APC/C activation and the consequent degradation of cell-cycle regulators and exit from meiosis. In this study, we show that a modest increase in the activity of the ubiquitin-conjugating enzyme UbcX overrides the meiotic arrest in an APC/C-dependent reaction. Intriguingly, XErp1 remains stable in these conditions. We found that UbcX causes the ubiquitylation of XErp1, followed by its dissociation from the APC/C. Our data support the idea that ubiquitylation regulates the APC/C-inhibitory activity of XErp1.</dcterms:abstract> <dc:contributor>Tischer, Thomas</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-17T08:03:06Z</dcterms:available> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-17T08:03:06Z</dc:date> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/13685"/> <dc:rights>deposit-license</dc:rights> <dc:creator>Hörmanseder, Eva</dc:creator> <dc:language>eng</dc:language> <dcterms:issued>2011-05</dcterms:issued> <dc:contributor>Mayer, Thomas</dc:contributor> <dc:contributor>Heubes, Simone</dc:contributor> <dc:creator>Stemmann, Olaf</dc:creator> <dcterms:bibliographicCitation>Publ. in: EMBO reports 12 (2011), 5, pp. 436-443</dcterms:bibliographicCitation> <dc:creator>Tischer, Thomas</dc:creator> <dc:creator>Heubes, Simone</dc:creator> <dcterms:title>Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1</dcterms:title> <dc:contributor>Stemmann, Olaf</dc:contributor> <dc:creator>Mayer, Thomas</dc:creator> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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