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Neuroplasticity-based training may normalise auditory gating in schizophrenia and improve verbal processing

Neuroplasticity-based training may normalise auditory gating in schizophrenia and improve verbal processing

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POPOV, Tzvetan, Todor JORDANOV, Gregory A. MILLER, Thomas ELBERT, Michael M. MERZENICH, Brigitte ROCKSTROH, 2009. Neuroplasticity-based training may normalise auditory gating in schizophrenia and improve verbal processing. In: Psychophysiology. 46(Suppl. 1), pp. S90

@article{Popov2009Neuro-1367, title={Neuroplasticity-based training may normalise auditory gating in schizophrenia and improve verbal processing}, year={2009}, number={Suppl. 1}, volume={46}, journal={Psychophysiology}, author={Popov, Tzvetan and Jordanov, Todor and Miller, Gregory A. and Elbert, Thomas and Merzenich, Michael M. and Rockstroh, Brigitte} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1367"> <dc:contributor>Rockstroh, Brigitte</dc:contributor> <dc:creator>Elbert, Thomas</dc:creator> <dcterms:abstract xml:lang="eng">An unusually large response ratio in the auditory paired-click task is a common finding for schizophrenia patients. In the present magnetoencephalographic (MEG) pairedclick design, sensory gating ratio (SGR) served to study effects of computer-based cognitive exercises (CE, Posit Science, SF), which emphasizes auditory discrimination and verbal memory, with the aim of improving signal-to-noise ratio of auditory/verbal processing in schizophrenia. Across 100 paired-click trials, M50 was scored as peak amplitude of the magnetic field 40 80 ms post S-onset; SGR were determined in source space (activity of two best-fitting equivalent current dipoles, one in each hemisphere). In an ongoing study, 21 patients (F20.0 ICD-10) exhibited higher SGR than 17 sex and age-matched healthy subjects, F(1, 39) 5 6.68, po.01. SGR tended to decrease during the course of CE (20 sessions within 4 weeks) in 12 patients, F(2, 10) 5 7.43, p o .01; right hemisphere SGR declined from .57 to .39, p o .01; left hemisphere .58 to .44, p 5 .09. No such decrease was observed in a 9 patients accomplishing standard cognitive training F(2, 7) 5 .36, p 5 .7 (Cogpack,Markersoftware). Performance in verbal memory improved only after CE (p o .01), though largely unrelated to SGR changes. Results indicate that MEG-based SGR assessment can track the course of successful auditory training and provide preliminary evidence that the auditory training tasks employed here provide a specific impact on sensory gating.</dcterms:abstract> <dc:contributor>Merzenich, Michael M.</dc:contributor> <dcterms:issued>2009</dcterms:issued> <dc:language>eng</dc:language> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:25:00Z</dcterms:available> <dc:contributor>Elbert, Thomas</dc:contributor> <dcterms:bibliographicCitation>Publ. in: Psychophysiology 46 (2009), Suppl. 1, pp. S90</dcterms:bibliographicCitation> <dc:creator>Jordanov, Todor</dc:creator> <dc:creator>Popov, Tzvetan</dc:creator> <dc:creator>Merzenich, Michael M.</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:25:00Z</dc:date> <dcterms:title>Neuroplasticity-based training may normalise auditory gating in schizophrenia and improve verbal processing</dcterms:title> <dc:contributor>Miller, Gregory A.</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1367"/> <dc:creator>Rockstroh, Brigitte</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:rights>deposit-license</dc:rights> <dc:contributor>Jordanov, Todor</dc:contributor> <dc:contributor>Popov, Tzvetan</dc:contributor> <dc:creator>Miller, Gregory A.</dc:creator> </rdf:Description> </rdf:RDF>

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