Receptor-mediated tumor targeting based on peptide hormones

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MEZŐ, Gábor, Marilena MANEA, 2010. Receptor-mediated tumor targeting based on peptide hormones. In: Expert opinion on drug delivery. 7(1), pp. 79-96. ISSN 1742-5247. eISSN 1744-7593. Available under: doi: 10.1517/17425240903418410

@article{Mezo2010Recep-13592, title={Receptor-mediated tumor targeting based on peptide hormones}, year={2010}, doi={10.1517/17425240903418410}, number={1}, volume={7}, issn={1742-5247}, journal={Expert opinion on drug delivery}, pages={79--96}, author={Mező, Gábor and Manea, Marilena} }

2011-07-31T22:25:04Z 2011-06-06T08:22:29Z deposit-license eng Manea, Marilena First publ. in: Expert opinion on drug delivery 7 (2010), 1, pp. 79-96, doi:10.1517/17425240903418410 Receptor-mediated tumor targeting based on peptide hormones 2010 Mező, Gábor Importance of the field: Tumor targeting with peptides is based on the discovery that receptors for many regulatory peptides are overexpressed in tumor cells, compared with their expression in normal tissues. Consequently, these peptides and their analogues can be used as carriers/targeting moieties for the preparation of diagnostic and therapeutic agents that have increased selectivity and decreased peripheral toxicity.<br />Areas covered in this review: Here an overview is given of the most relevant gonadotropin-releasing hormone (GnRH) and somatostatin derivatives, as well as of their applications in cancer diagnosis and therapy. For this purpose, recently published data in these areas (mostly articles published from 2000 to 2009) were reviewed.<br />What the reader will gain: In contrast to other regulatory peptides that stimulate the tumor growth, GnRH and somatostatin derivatives have inhibitory effect; therefore, they were used primarily for the preparation of various conjugates to be used in targeted chemotherapy, targeted radiotherapy, photodynamic therapy, boron neutron capture therapy and cancer diagnosis. Some of these conjugates have already found clinical applications, whereas others are now in preclinical and clinical trials.<br />Take home message: Tumor targeting with hormone peptides provides a basis for the development of new diagnostic and therapeutic approaches for cancer. Manea, Marilena Mező, Gábor

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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