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Genetic, Comparative Genomic, and Expression Analyses of the Mc1r Locus in the Polychromatic Midas Cichlid Fish (Teleostei, Cichlidae Amphilophus sp.) Species Group

Genetic, Comparative Genomic, and Expression Analyses of the Mc1r Locus in the Polychromatic Midas Cichlid Fish (Teleostei, Cichlidae Amphilophus sp.) Species Group

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HENNING, Frederico, Adina RENZ, Shoji FUKAMACHI, Axel MEYER, 2010. Genetic, Comparative Genomic, and Expression Analyses of the Mc1r Locus in the Polychromatic Midas Cichlid Fish (Teleostei, Cichlidae Amphilophus sp.) Species Group. In: Journal of Molecular Evolution. 70(5), pp. 405-412. ISSN 0022-2844. eISSN 1432-1432

@article{Henning2010Genet-13578, title={Genetic, Comparative Genomic, and Expression Analyses of the Mc1r Locus in the Polychromatic Midas Cichlid Fish (Teleostei, Cichlidae Amphilophus sp.) Species Group}, year={2010}, doi={10.1007/s00239-010-9340-4}, number={5}, volume={70}, issn={0022-2844}, journal={Journal of Molecular Evolution}, pages={405--412}, author={Henning, Frederico and Renz, Adina and Fukamachi, Shoji and Meyer, Axel} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/13578"> <dc:rights>deposit-license</dc:rights> <dcterms:title>Genetic, Comparative Genomic, and Expression Analyses of the Mc1r Locus in the Polychromatic Midas Cichlid Fish (Teleostei, Cichlidae Amphilophus sp.) Species Group</dcterms:title> <dc:creator>Henning, Frederico</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:contributor>Meyer, Axel</dc:contributor> <dcterms:issued>2010</dcterms:issued> <dc:creator>Fukamachi, Shoji</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-10T07:12:04Z</dcterms:available> <dc:creator>Renz, Adina</dc:creator> <dc:contributor>Fukamachi, Shoji</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/13578"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-10T07:12:04Z</dc:date> <dc:language>eng</dc:language> <dc:contributor>Henning, Frederico</dc:contributor> <dcterms:abstract xml:lang="eng">Natural populations of the Midas cichlid species in several different crater lakes in Nicaragua exhibit a conspicuous color polymorphism. Most individuals are dark and the remaining have a gold coloration. The color morphs mate assortatively and sympatric population differentiation has been shown based on neutral molecular data. We investigated the color polymorphism using segregation analysis and a candidate gene approach. The segregation patterns observed in a mapping cross between a gold and a dark individual were consistent with a single dominant gene as a cause of the gold phenotype. This suggests that a simple genetic architecture underlies some of the speciation events in the Midas cichlids. We compared the expression levels of several candidate color genes Mc1r, Ednrb1, Slc45a2, and Tfap1a between the color morphs. Mc1r was found to be up regulated in the gold morph. Given its widespread association in color evolution and role on melanin synthesis, the Mc1r locus was further investigated using sequences derived from a genomic library. Comparative analysis revealed conserved synteny in relation to the majority of teleosts and highlighted several previously unidentified conserved non-coding elements (CNEs) in the upstream and downstream regions in the vicinity of Mc1r. The identification of the CNEs regions allowed the comparison of sequences from gold and dark specimens of natural populations. No polymorphisms were found between in the population sample and Mc1r showed no linkage to the gold phenotype in the mapping cross, demonstrating that it is not causally related to the color polymorphism in the Midas cichlid.</dcterms:abstract> <dc:contributor>Renz, Adina</dc:contributor> <dc:creator>Meyer, Axel</dc:creator> <dcterms:bibliographicCitation>First publ. in: Journal of Molecular Evolution 70 (2010), 5, pp. 405-412, DOI: 10.1007/s00239-010-9340-4</dcterms:bibliographicCitation> </rdf:Description> </rdf:RDF>

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