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Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri)

Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri)

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OPPELT, Claus, Rebecca WUTZLER, Dietrich von HOLST, 2010. Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri). In: Immunogenetics. 62(9), pp. 613-622. ISSN 0093-7711. eISSN 1432-1211

@article{Oppelt2010Chara-13572, title={Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri)}, year={2010}, number={9}, volume={62}, issn={0093-7711}, journal={Immunogenetics}, pages={613--622}, author={Oppelt, Claus and Wutzler, Rebecca and Holst, Dietrich von}, note={Electronic supplementary material The online version of this article (doi:10.1007/s00251-010-0466-8) contains supplementary material, which is available to authorized users.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/13572"> <dc:language>eng</dc:language> <dc:contributor>Oppelt, Claus</dc:contributor> <dcterms:title>Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri)</dcterms:title> <dcterms:bibliographicCitation>First publ. in: Immunogenetics 62 (2010), 9, pp. 613-622, DOI: 10.1007/s00251-010-0466-8</dcterms:bibliographicCitation> <dcterms:abstract xml:lang="eng">Genes of the major histocompatibility complex (MHC) mainly code for proteins of the immune system of jawed vertebrates. In particular, MHC class I and II cell surface proteins are crucial for the self/non-self discrimination of the adaptive immune system and are the most polymorphic genes in vertebrates. Positive selection, gene duplications and pseudogenes shape the face of the MHC and reflect a highly dynamic evolution. Here, we present for the first time data of the highly polymorphic MHC class II DRB exon 2 of a representative of the mammalian order scandentia, the northern tree shrew Tupaia belangeri. We found up to eight different alleles per individual and determined haplotype constitution by intensively studying their inheritance. The alleles were assigned to four putative loci, all of which were polymorphic. Only the most polymorphic locus was subject to positive selection within the antigen binding sites and only alleles of this locus were transcribed.</dcterms:abstract> <dc:rights>deposit-license</dc:rights> <dc:creator>Holst, Dietrich von</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/13572"/> <dc:creator>Oppelt, Claus</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Wutzler, Rebecca</dc:creator> <dcterms:issued>2010</dcterms:issued> <dc:contributor>Wutzler, Rebecca</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-01T14:01:21Z</dc:date> <dc:contributor>Holst, Dietrich von</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-30T22:25:05Z</dcterms:available> </rdf:Description> </rdf:RDF>

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