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Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN)

Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN)

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KARAMITOPOULOU, Eva, Inti ZLOBEC, Luigi TORNILLO, Vincenza CARAFA, Thomas SCHAFFNER, Thomas BRUNNER, Markus BORNER, Ioannis DIAMANTIS, Arthur ZIMMERMANN, Luigi TERRACCIANO, 2010. Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN). In: Pathology. 42(3), pp. 229-234. ISSN 0031-3025. eISSN 1465-3931. Available under: doi: 10.3109/00313021003631379

@article{Karamitopoulou2010-04Diffe-13538, title={Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN)}, year={2010}, doi={10.3109/00313021003631379}, number={3}, volume={42}, issn={0031-3025}, journal={Pathology}, pages={229--234}, author={Karamitopoulou, Eva and Zlobec, Inti and Tornillo, Luigi and Carafa, Vincenza and Schaffner, Thomas and Brunner, Thomas and Borner, Markus and Diamantis, Ioannis and Zimmermann, Arthur and Terracciano, Luigi} }

Zimmermann, Arthur Karamitopoulou, Eva Tornillo, Luigi Diamantis, Ioannis Brunner, Thomas Brunner, Thomas Diamantis, Ioannis Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN) Borner, Markus Schaffner, Thomas Terracciano, Luigi Carafa, Vincenza Karamitopoulou, Eva eng Zlobec, Inti Tornillo, Luigi 2010-04 Carafa, Vincenza Aims:: Pancreatic cancer is an aggressive tumour following a multistep progression model through precursors called pancreatic intraepithelial neoplasia (PanIN). Identification of reliable prognostic markers would help in improving survival. The aim of this study was to investigate the role as well as the prognostic significance of different cell cycle and proliferation markers, namely p21, p27, p53 and Ki‐67, in pancreatic carcinogenesis.<br /><br />Methods:: We analysed the expression of p21, p27, p53 and Ki‐67, in 210 ductal pancreatic adenocarcinomas, 40 PanIN‐3 cases and 40 normal controls combined in a tissue microarray. The results were correlated with clinicopathological and follow‐up data.<br /><br />Results:: Our study revealed a differential p27, p21, p53, and Ki‐67 expression between ductal adenocarcinoma, PanIN‐3 and normal pancreas. p27 expression progressively decreased from normal pancreas to PanIN and to pancreatic cancer. Decreased p27 and increased p53 expression showed a significant association with the T stage. A Ki‐67 >5% correlated with reduced survival.<br /><br />Conclusions:: In pancreatic cancer, loss of p27 and increased p53 expression is associated with a more aggressive phenotype. p27 may play an important role in pancreatic carcinogenesis. A Ki‐67 >5% independently predicted poor outcome. Schaffner, Thomas Zlobec, Inti deposit-license Borner, Markus First publ. in: Pathology 42 (2010), 3. - pp. 229-234 2011-05-31T09:54:28Z Zimmermann, Arthur Terracciano, Luigi 2011-05-31T09:54:28Z

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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