Control of death receptor ligand activity by posttranslational modifications

Weinlich, Ricardo; Brunner, Thomas; Amarante-Mendes, Gustavo P.

Control of death receptor ligand activity by posttranslational modifications

Files

2010_Control_of_death_Weinlich.pdf(1.6 MB)

Date

2010

Authors

Weinlich, Ricardo

Brunner, Thomas

Amarante-Mendes, Gustavo P.

Publisher

Springer

Publication type

Journal article

Published in

Cellular and Molecular Life Sciences ; 67 (2010), 10. - pp. 1631-1642. - ISSN 1420-682X. - eISSN 1420-9071

Abstract

The death receptor ligands are involved in many physiological and pathological processes involving triggering of apoptosis, inflammation, proliferation, and activation. The expression of these molecules is reported to be tightly regulated at the transcriptional level. However, over the last few years, an increasing number of data demonstrated that the control of transcription is only one of the mechanisms that manage the expression of the death receptor ligands. Thus, this review is focused on posttranslational regulation of the three main members of this family, namely FasL, TNF-α, and TRAIL. We discuss here the importance of distribution, storage, and degranulation of these molecules, as well as their shedding by proteases on the control of death receptor ligands expression and activity.

Subject (DDC)

570 Biosciences, Biology

Keywords

FasL,TNF,TRAIL,Rafts,Lysosomes,Degranulation,ADAM,Metalloprotease,Shedding

Cite This

ISO 690

WEINLICH, Ricardo, Thomas BRUNNER, Gustavo P. AMARANTE-MENDES, 2010. Control of death receptor ligand activity by posttranslational modifications. Springer. In: Cellular and Molecular Life Sciences. 67(10), pp. 1631-1642. ISSN 1420-682X. eISSN 1420-9071. Available under: doi: 10.1007/s00018-010-0289-7

BibTex

@article{Weinlich2010Contr-13537,
  year={2010},
  doi={10.1007/s00018-010-0289-7},
  title={Control of death receptor ligand activity by posttranslational modifications},
  number={10},
  volume={67},
  issn={1420-682X},
  journal={Cellular and Molecular Life Sciences},
  pages={1631--1642},
  author={Weinlich, Ricardo and Brunner, Thomas and Amarante-Mendes, Gustavo P.}
}

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