KOPS - Das Institutionelle Repositorium der Universität Konstanz

Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:65bc35816af0c0004f2e00bd70f5f9fe

LAI, Yuping, Anna Di NARDO, Teruaki NAKATSUJI, Anke LEICHTLE, Yan YANG, Anna L. COGEN, Zi-Rong WU, Lora V. HOOPER, Richard R. SCHMIDT, Sonja VON AULOCK, Katherine A. RADEK, Chun-Ming HUANG, Allen F. RYAN, Richard L. GALLO, 2009. Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury. Nature Publ. Co.. In: Nature Medicine. 15(12), pp. 1377-1382. ISSN 1078-8956. eISSN 1546-170X. Available under: doi: 10.1038/nm.2062

@article{Lai2009Comme-13535, title={Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury}, year={2009}, doi={10.1038/nm.2062}, number={12}, volume={15}, issn={1078-8956}, journal={Nature Medicine}, pages={1377--1382}, author={Lai, Yuping and Nardo, Anna Di and Nakatsuji, Teruaki and Leichtle, Anke and Yang, Yan and Cogen, Anna L. and Wu, Zi-Rong and Hooper, Lora V. and Schmidt, Richard R. and von Aulock, Sonja and Radek, Katherine A. and Huang, Chun-Ming and Ryan, Allen F. and Gallo, Richard L.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/13535"> <dc:creator>Leichtle, Anke</dc:creator> <dc:creator>Nardo, Anna Di</dc:creator> <dc:contributor>Yang, Yan</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-05-30T07:56:35Z</dc:date> <dcterms:title>Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury</dcterms:title> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-07-31T22:25:04Z</dcterms:available> <dcterms:issued>2009</dcterms:issued> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>von Aulock, Sonja</dc:contributor> <dc:contributor>Leichtle, Anke</dc:contributor> <dc:contributor>Nardo, Anna Di</dc:contributor> <dc:contributor>Nakatsuji, Teruaki</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/13535"/> <dcterms:abstract xml:lang="eng">The normal microflora of the skin includes staphylococcal species that will induce inflammation when present below the dermis but are tolerated on the epidermal surface without initiating inflammation. Here we reveal a previously unknown mechanism by which a product of staphylococci inhibits skin inflammation. This inhibition is mediated by staphylococcal lipoteichoic acid (LTA) and acts selectively on keratinocytes triggered through Toll-like receptor 3(TLR3). We show that TLR3 activation is required for normal inflammation after injury and that keratinocytes require TLR3 to respond to RNA from damaged cells with the release of inflammatory cytokines. Staphylococcal LTA inhibits both inflammatory cytokine release from keratinocytes and inflammation triggered by injury through a TLR2-dependent mechanism. To our knowledge, these findings show for the first time that the skin epithelium requires TLR3 for normal inflammation after wounding and that the microflora can modulate specific cutaneous inflammatory responses.</dcterms:abstract> <dc:contributor>Hooper, Lora V.</dc:contributor> <dc:contributor>Gallo, Richard L.</dc:contributor> <dc:creator>Gallo, Richard L.</dc:creator> <dc:contributor>Schmidt, Richard R.</dc:contributor> <dc:creator>Nakatsuji, Teruaki</dc:creator> <dc:contributor>Wu, Zi-Rong</dc:contributor> <dc:contributor>Lai, Yuping</dc:contributor> <dc:creator>Schmidt, Richard R.</dc:creator> <dc:creator>Ryan, Allen F.</dc:creator> <dc:contributor>Ryan, Allen F.</dc:contributor> <dc:creator>Hooper, Lora V.</dc:creator> <dc:rights>deposit-license</dc:rights> <dc:creator>Lai, Yuping</dc:creator> <dc:language>eng</dc:language> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/13535/1/nm.2062.pdf"/> <dcterms:bibliographicCitation>First publ. in: Nature Medicine 15 (2009), 12, pp. 1377-1382</dcterms:bibliographicCitation> <dc:publisher>Nature Publ. Co.</dc:publisher> <dc:creator>Huang, Chun-Ming</dc:creator> <dc:creator>Wu, Zi-Rong</dc:creator> <dc:creator>Yang, Yan</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/13535/1/nm.2062.pdf"/> <dc:creator>von Aulock, Sonja</dc:creator> <dc:contributor>Huang, Chun-Ming</dc:contributor> <dc:contributor>Radek, Katherine A.</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Radek, Katherine A.</dc:creator> <dc:contributor>Cogen, Anna L.</dc:contributor> <dc:creator>Cogen, Anna L.</dc:creator> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

nm.2062.pdf 206

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto