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Conservation of shh cis-regulatory architecture of the coelacanth is consistent with its ancestral phylogenetic position

Conservation of shh cis-regulatory architecture of the coelacanth is consistent with its ancestral phylogenetic position

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MEYER, Axel, Michael LANG, Nicol SIEGEL, May-Britt BECKER, Yavor HADZHIEV, Chris T. AMEMIYA, Carolina PARADA, Uwe STRÄHLE, Ferenc MÜLLER, 2010. Conservation of shh cis-regulatory architecture of the coelacanth is consistent with its ancestral phylogenetic position. In: EvoDevo. 1(11), pp. 1-13. ISSN 2041-9139. eISSN 2041-9139

@article{Meyer2010Conse-13530, title={Conservation of shh cis-regulatory architecture of the coelacanth is consistent with its ancestral phylogenetic position}, year={2010}, doi={10.1186/2041-9139-1-11}, number={11}, volume={1}, issn={2041-9139}, journal={EvoDevo}, pages={1--13}, author={Meyer, Axel and Lang, Michael and Siegel, Nicol and Becker, May-Britt and Hadzhiev, Yavor and Amemiya, Chris T. and Parada, Carolina and Strähle, Uwe and Müller, Ferenc} }

2011-05-27T08:48:11Z Siegel, Nicol Amemiya, Chris T. Background:<br /><br />The modern coelacanth (Latimeria) is the extant taxon of a basal sarcopterygian lineage and sister group to tetrapods. Apart from certain apomorphic traits, its morphology is characterized by a high degree of retention of ancestral vertebrate structures and little morphological change. An insight into the molecular evolution that may explain the unchanged character of Latimeria morphology requires the analysis of the expression patterns of developmental regulator genes and their cis-regulatory modules (CRMs).<br /><br />Results:<br /><br />We describe the comparative and functional analysis of the sonic hedgehog (shh) genomic region of Latimeria menadoensis. Several putative enhancers in the Latimeria shh locus have been identified by comparisons to sarcopterygian and actinopterygian extant species. Specific sequence conservation with all known actinopterygian enhancer elements has been detected. However, these elements are selectively missing in more recently diverged actinopterygian and sarcopterygian species. The functionality of the putative Latimeria enhancers was confirmed by reporter gene expression analysis in transient transgenic zebrafish and chick embryos.<br /><br />Conclusions:<br /><br />Latimeria shh CRMs represent the ancestral set of enhancers that have emerged before the split of lobe-finned and ray-finned fishes. In contrast to lineage-specific losses and differentiations in more derived lineages, Latimeria shh enhancers reveal low levels of sequence diversification. High overall sequence conservation of shh conserved noncoding elements (CNE) is consistent with the general trend of high levels of conservation of noncoding DNA in the slowly evolving Latimeria genome. Parada, Carolina Müller, Ferenc eng Strähle, Uwe Amemiya, Chris T. 2010 Meyer, Axel Conservation of shh cis-regulatory architecture of the coelacanth is consistent with its ancestral phylogenetic position Hadzhiev, Yavor First publ. in: EvoDevo 1 (2010), 11, pp. 1-13 Siegel, Nicol Müller, Ferenc Strähle, Uwe Lang, Michael 2011-05-27T08:48:11Z Becker, May-Britt Lang, Michael Hadzhiev, Yavor Becker, May-Britt Meyer, Axel Parada, Carolina deposit-license

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