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Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age

Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age

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Prüfsumme: MD5:2c64ae3c72730ee735234b56bb32a427

LEIRER, Vera Maria, Christian WIENBRUCH, Isabella PAUL-JORDANOV, Stephan KOLASSA, Thomas ELBERT, Iris KOLASSA, 2010. Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age. In: BMC Neuroscience. 11(1), 113. eISSN 1471-2202. Available under: doi: 10.1186/1471-2202-11-113

@article{Leirer2010Hippo-13423, title={Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age}, year={2010}, doi={10.1186/1471-2202-11-113}, number={1}, volume={11}, journal={BMC Neuroscience}, author={Leirer, Vera Maria and Wienbruch, Christian and Paul-Jordanov, Isabella and Kolassa, Stephan and Elbert, Thomas and Kolassa, Iris}, note={Article Number: 113} }

Paul-Jordanov, Isabella eng Elbert, Thomas Wienbruch, Christian Kolassa, Stephan Elbert, Thomas Kolassa, Iris 2011-05-24T12:26:06Z Background: The hippocampus is a brain region that is particularly affected by age-related morphological changes. It is generally assumed that a loss in hippocampal volume results in functional deficits that contribute to age-related cognitive decline. In a combined cross-sectional behavioural and magnetoencephalography (MEG) study we investigated whether hippocampal-associated neural current flow during a transverse patterning task - which requires learning relational associations between stimuli - correlates with age and whether it is modulated by cognitive competence.<br />Results: Better performance in several tests of verbal memory, verbal fluency and executive function was indeed associated with higher hippocampal neural activity. Age, however, was not related to the strength of hippocampal neural activity: elderly participants responded slower than younger individuals but on average produced the same neural mass activity.<br />Conclusions: Our results suggest that in non-pathological aging, hippocampal neural activity does not decrease with age but is rather related to cognitive competence. Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age BMC Neuroscience ; 11 (2010). - 113 Kolassa, Iris deposit-license 2010 Leirer, Vera Maria Wienbruch, Christian Leirer, Vera Maria Paul-Jordanov, Isabella 2011-05-24T12:26:06Z Kolassa, Stephan

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