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Association Study of Trauma Load and SLC6A4 Promoter Polymorphism in Posttraumatic Stress Disorder : Evidence From Survivors of the Rwandan Genocide

Association Study of Trauma Load and SLC6A4 Promoter Polymorphism in Posttraumatic Stress Disorder : Evidence From Survivors of the Rwandan Genocide

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Prüfsumme: MD5:571d2adc8bb0ac959327982410d20eae

KOLASSA, Iris, Verena ERTL, Cindy ECKART, Franka GLÖCKNER, Stephan KOLASSA, Andreas PAPASSOTIROPOULOS, Dominique J.-F. de QUERVAIN, Thomas ELBERT, 2010. Association Study of Trauma Load and SLC6A4 Promoter Polymorphism in Posttraumatic Stress Disorder : Evidence From Survivors of the Rwandan Genocide. In: Journal of Clinical Psychiatry. 71(5), pp. 543-547

@article{Kolassa2010Assoc-13420, title={Association Study of Trauma Load and SLC6A4 Promoter Polymorphism in Posttraumatic Stress Disorder : Evidence From Survivors of the Rwandan Genocide}, year={2010}, doi={10.4088/JCP.08m04787blu}, number={5}, volume={71}, journal={Journal of Clinical Psychiatry}, pages={543--547}, author={Kolassa, Iris and Ertl, Verena and Eckart, Cindy and Glöckner, Franka and Kolassa, Stephan and Papassotiropoulos, Andreas and Quervain, Dominique J.-F. de and Elbert, Thomas} }

Glöckner, Franka Glöckner, Franka deposit-license 2011-05-24T06:09:16Z Elbert, Thomas Quervain, Dominique J.-F. de eng Elbert, Thomas Objective: As exposure to different types of traumatic stressors increases, the occurrence of posttraumatic stress disorder (PTSD) increases. However, because some people exhibit either surprising resilience or high vulnerability, further influencing factors have been conjectured, such as gene-environment interactions. The SLC6A4 gene, which encodes serotonin transporter, has been identified as predisposing toward differential emotional processing between genotypes of its promoter polymorphism.<br />Method: We investigated 408 refugees from the Rwandan genocide and assessed lifetime exposure to traumatic events, PTSD (according to DSM-IV) status, and genotype of the SLC6A4 promoter polymorphism. The study was conducted from March 2006 to February 2007.<br />Results: The prevalence of PTSD approached<br />100% when traumatic exposure reached extreme levels. However, persons homozygous for the short allele of the SLC6A4 promoter polymorphism showed no dose-response relationship but were at high risk for developing PTSD after very few traumatic events. This genotype influence vanished with increasing exposure to traumatic stressors. Conclusion: We find evidence for a geneenvironment interplay for PTSD and show that genetic influences lose importance when environmental factors cause an extremely high trauma burden to an individual. In the future, it may be important to determine whether the effectiveness of therapeutic interventions in PTSD is also modulated by the SLC6A4 genotype. 2010 Quervain, Dominique J.-F. de Kolassa, Stephan Kolassa, Iris Kolassa, Iris 2011-05-24T06:09:16Z Papassotiropoulos, Andreas First publ. in: Journal of Clinical Psychiatry ; 71 (2010), 5. - S. 543 - 547 Eckart, Cindy Papassotiropoulos, Andreas Association Study of Trauma Load and SLC6A4 Promoter Polymorphism in Posttraumatic Stress Disorder : Evidence From Survivors of the Rwandan Genocide Eckart, Cindy Ertl, Verena Ertl, Verena Kolassa, Stephan

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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