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Enhanced neural drive after maximal strength training in multiple sclerosis patients

Enhanced neural drive after maximal strength training in multiple sclerosis patients

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Prüfsumme: MD5:b56bfd30f32bc1ac094b16c74b5cb83b

FIMLAND, Marius S., Jan HELGERUD, Markus GRUBER, Gunnar LEIVSETH, Jan HOFF, 2010. Enhanced neural drive after maximal strength training in multiple sclerosis patients. In: European Journal of Applied Physiology. 110(2), pp. 435-443. ISSN 1439-6319. eISSN 1439-6327. Available under: doi: 10.1007/s00421-010-1519-2

@article{Fimland2010-09Enhan-12787, title={Enhanced neural drive after maximal strength training in multiple sclerosis patients}, year={2010}, doi={10.1007/s00421-010-1519-2}, number={2}, volume={110}, issn={1439-6319}, journal={European Journal of Applied Physiology}, pages={435--443}, author={Fimland, Marius S. and Helgerud, Jan and Gruber, Markus and Leivseth, Gunnar and Hoff, Jan} }

Fimland, Marius S. 2011-06-27T17:16:09Z Hoff, Jan 2011-06-27T17:16:09Z 2010-09 Helgerud, Jan Leivseth, Gunnar Fimland, Marius S. Helgerud, Jan Enhanced neural drive after maximal strength training in multiple sclerosis patients Gruber, Markus Hoff, Jan deposit-license First publ. in: European Journal of Applied Physiology 110 (2010), 2, pp. 435-443 eng Leivseth, Gunnar Multiple sclerosis (MS) patients suffer from impaired muscle activation and lower limb strength. Strength training enhances muscle activation and muscle strength, but neural adaptations to strength training remain unexplored in MS patients. The hypothesis was that maximal strength training (MST) using high loads and few repetitions would improve central neural drive and thus strength capacity of MS patients. 14 MS patients staying at a national MS rehabilitation center were randomly assigned to a MST group or a control group (CG). Both groups received “today’s treatment”. In addition, the MST group trained 4 × 4 repetitions of unilateral dynamic leg press and plantar flexion 5 days a week for 3 weeks. Neural adaptations of the soleus muscle were assessed by surface electromyography (EMG) activity, and by superimposed H-reflexes and V-waves obtained during maximum voluntary isometric plantar flexor contractions (MVCs). H-reflexes and V-waves were normalized by the M-wave (H SUP/M SUP, V/M SUP, respectively). In the MST group, MVC increased by 20 ± 9% (P < 0.05). Soleus EMG activity and V/M SUP ratio increased by 40 and 55%, respectively, in the MST group compared to the CG (P ≤ 0.05). The H SUP/M SUP ratio remained unchanged. No change was apparent in the CG. MST group subjects were able to complete all training sessions. No adverse effects were reported. This randomized study provides evidence that MST is effective of augmenting the magnitude of efferent motor output of spinal motor neurons in MS patients, alleviating some neuromuscular symptoms linked to the disease. Gruber, Markus

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