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Evolutionary History and Functional Characterization of Androgen Receptor Genes in Jawed Vertebrates

Evolutionary History and Functional Characterization of Androgen Receptor Genes in Jawed Vertebrates

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OGINO, Yukiko, Hironori KATOH, Shigehiro KURAKU, Gen YAMADA, 2009. Evolutionary History and Functional Characterization of Androgen Receptor Genes in Jawed Vertebrates. In: Endocrinology. 150(12), pp. 5415-5427. ISSN 0013-7227. eISSN 1945-7170. Available under: doi: 10.1210/en.2009-0523

@article{Ogino2009Evolu-1265, title={Evolutionary History and Functional Characterization of Androgen Receptor Genes in Jawed Vertebrates}, year={2009}, doi={10.1210/en.2009-0523}, number={12}, volume={150}, issn={0013-7227}, journal={Endocrinology}, pages={5415--5427}, author={Ogino, Yukiko and Katoh, Hironori and Kuraku, Shigehiro and Yamada, Gen} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1265"> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Katoh, Hironori</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1265"/> <dc:creator>Yamada, Gen</dc:creator> <dc:contributor>Ogino, Yukiko</dc:contributor> <dc:creator>Ogino, Yukiko</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:contributor>Katoh, Hironori</dc:contributor> <dc:contributor>Kuraku, Shigehiro</dc:contributor> <dc:language>eng</dc:language> <dcterms:bibliographicCitation>Publ. in: Endocrinology 150 (2009), 12, pp. 5415-5427</dcterms:bibliographicCitation> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:07:31Z</dcterms:available> <dc:creator>Kuraku, Shigehiro</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:rights>deposit-license</dc:rights> <dcterms:issued>2009</dcterms:issued> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:07:31Z</dc:date> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:abstract xml:lang="eng">Vertebrates show diverse sexual characters in sexually attractive and reproductive organs, which are regulated by steroid hormones, particularly androgens. However, the evolutionary history of androgen receptor (AR) gene remains largely unknown on the basis of phylogenic and functional analyses. To elucidate the evolutionary history and functional diversification of AR genes in vertebrates, we cloned the AR cDNAs from a shark, basal ray-finned fishes (Actinopterygii), namely bichir and sturgeon (Acipenseriformes), and teleosts including a basal teleost, arowana (Osteoglossiformes). Molecular phylogenetic analysis revealed that the gene duplication event that gave rise to two different teleost ARs ({alpha} and β) likely occurred in the actinopterygian lineage leading to teleosts after the divergence of Acipenseriformes but before the split of Osteoglossiformes, which is compatible with the phylogenetic timing of teleost-specific genome duplication. Searching for AR genes in the medaka genome indicated that the teleost AR gene duplication has been associated with the duplication between chromosomes 10 and 14. Our functional analysis revealed that the shark AR activates the target gene via androgen response element by classical androgens. The teleost AR{alpha} showed the unique intracellular localization with a significantly higher transactivating capacity than that by teleost ARβ. These findings indicate that the most ancient type of AR, as activated by the classical androgens as ligands, emerged before the Chondrichthyes-Osteichthyes split, and the AR gene was duplicated during the teleost-specific genome duplication event. We report here for the first time the accurate evolutionary history of AR gene and functional characterization of AR duplicates in teleost lineage.</dcterms:abstract> <dcterms:title>Evolutionary History and Functional Characterization of Androgen Receptor Genes in Jawed Vertebrates</dcterms:title> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Yamada, Gen</dc:contributor> </rdf:Description> </rdf:RDF>

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