Synthesis of Water-Soluble Phosphinophenol for Traceless Staudinger Ligation
| Type of Publication: | Journal article |
| URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-126020 |
| Author: | Weisbrod, Samuel H.; Marx, Andreas |
| Year of publication: | 2010 |
| Published in: | Synlett ; 2010 (2010), 05. - pp. 787-789. - ISSN 0936-5214 |
| DOI (citable link): | https://dx.doi.org/10.1055/s-0029-1219353 |
| Summary: |
The traceless Staudinger ligation can be mediated in water without organic co-solvents if charged groups render the phenylphosphine reagent water soluble. Here the synthesis of a new water-soluble phosphine is presented based on a diphenylphosphinophenol reagent. Staudinger ligation with this reagent and azido glycine amide showed conversion of 77%.
|
| Subject (DDC): | 540 Chemistry |
| Keywords: | amide, phenol, Staudinger ligation, conjugation, phosphine |
| Link to License: | In Copyright |
| Bibliography of Konstanz: | Yes |
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WEISBROD, Samuel H., Andreas MARX, 2010. Synthesis of Water-Soluble Phosphinophenol for Traceless Staudinger Ligation. In: Synlett. 2010(05), pp. 787-789. ISSN 0936-5214. Available under: doi: 10.1055/s-0029-1219353
@article{Weisbrod2010Synth-12602, title={Synthesis of Water-Soluble Phosphinophenol for Traceless Staudinger Ligation}, year={2010}, doi={10.1055/s-0029-1219353}, number={05}, volume={2010}, issn={0936-5214}, journal={Synlett}, pages={787--789}, author={Weisbrod, Samuel H. and Marx, Andreas} }
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