Analysis and expression of a cloned pre-T cell receptor gene

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SAINT-RUF, Claude, Katharina UNGEWISS, Marcus GROETTRUP, Ludovica BRUNO, Hans Jörg FEHLING, Harald von BOEHMER, 2009. Analysis and expression of a cloned pre-T cell receptor gene. In: The Journal of Immunology. 182(9), pp. 5165-5169

@article{Saint-Ruf2009Analy-1252, title={Analysis and expression of a cloned pre-T cell receptor gene}, year={2009}, number={9}, volume={182}, journal={The Journal of Immunology}, pages={5165--5169}, author={Saint-Ruf, Claude and Ungewiss, Katharina and Groettrup, Marcus and Bruno, Ludovica and Fehling, Hans Jörg and Boehmer, Harald von} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/1252"> <dc:creator>Groettrup, Marcus</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:07:26Z</dcterms:available> <dc:contributor>Groettrup, Marcus</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:07:26Z</dc:date> <dc:creator>Boehmer, Harald von</dc:creator> <dc:contributor>Saint-Ruf, Claude</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Ungewiss, Katharina</dc:contributor> <dc:creator>Fehling, Hans Jörg</dc:creator> <dc:contributor>Bruno, Ludovica</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1252"/> <dcterms:issued>2009</dcterms:issued> <dc:contributor>Boehmer, Harald von</dc:contributor> <dc:creator>Ungewiss, Katharina</dc:creator> <dc:creator>Bruno, Ludovica</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dcterms:title>Analysis and expression of a cloned pre-T cell receptor gene</dcterms:title> <dc:contributor>Fehling, Hans Jörg</dc:contributor> <dcterms:bibliographicCitation>Publ. in: The Journal of Immunology 182 (2009), 9, pp. 5165-5169</dcterms:bibliographicCitation> <dc:creator>Saint-Ruf, Claude</dc:creator> <dcterms:abstract xml:lang="eng">The T cell antigen receptor (TCR) p chain regulates early T cell development in the absence of the TCRa chain. The developmentally controlled gene described here encodes the pre-TCRa (pTa) chain, which covalently associates with TCRp and with the CD3 proteins forms a pre-TCR complex that transduces signals in immature thymocytes. Unlike the λ5 pre-B cell receptor protein, the pTa chain is a type I transmembrane protein whose cytoplasmic tail contains two potential phosphorylation sites and a Src homology 3 (SH3)-domain binding sequence. Pre-TCRa transfection experiments indicated that surface expression of the pre-TCR is controlled by additional developmentally regulated proteins. Identification of the pTa gene represents an essential step in the structure-function analysis of the pre-TCR complex.</dcterms:abstract> <dc:rights>deposit-license</dc:rights> </rdf:Description> </rdf:RDF>

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